When is Daklinza contraindicated?
The following chart provides information regarding potentially significant drug interactions with Daklinza (the table is not all-inclusive). Alteration in dose or regimen may be recommended based on drug interaction studies or predicted interactions. (For more information regarding the effect of co-administration of these medications with Daklinza and recommendations for alterations in dose or regimen please visit www.Daklinza.com.)
|Drug Class||Specific Drugs Within Class Contraindicated with Daklinza|
|Strong CYP3A Inhibitors||Atazanavir/ritonavir Clarithromycin Indinavir Itraconazole Ketoconazole Nefazodone Nelfinavir Posaconazole Saquinavir Telithromycin Voricanazole|
|Moderate CYP3A Inhibitors||Atazanavir Ciprofloxacin Darunavir/ritonavir Diltiazem Erythromycin Fluconazole Fosamprenavir Verapamil|
|Moderate CYP3A Inducers||Bosentan Dexamethasone Efavirenz Etravirine Modafinil Nafcillin Rifapentine|
|Anticoagulants||Dabigatran Etexilate Mesylate|
|Cardiovascular Agents||Amiodarone Digoxin|
|Lipid Lower Agents||Atorvastatin Fluvastatin Pitavastatin Pravastatin Rosuvastatin Simvastatin|
While the following drugs were evaluated in clinical trials, when used individually with Daklinza they had no clinically significant interactions:
- ethinyl estradiol/norgestimate
Last Updated: July 2015
FDA Approved Daklinza (Daclatasvir) for the Treatment of Patients with Chronic Hepatitis C Genotype 3. http://news.bms.com/press-release/fda-approves-daklinza-daclatasvir-treatment-patients-chronic-hepatitis-c-genotype-3, Bristol-Myers Squibb Company. Retrieved July 27, 2015.
Financial Help Info for Daklinza (daclatasvir) . http://www.daklinza.bmscustomerconnect.com/support, Bristol-Myers Squibb Company. Retrieved July 27, 2015.
Highlights of Prescribing Information - DAKLINZA. http://packageinserts.bms.com/pi/pi_daklinza.pdf, Bristol-Myers Squibb Company. Retrieved July 27, 2015.
Patient Support Connect. http://www.patientsupportconnect.bmscustomerconnect.com/, Bristol-Myers Squibb Company. Retrieved July 27, 2015.