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“+1”>Modified Staging: architectural changes, fibrosis and cirrhosis*
Change Score
No fibrosis 0
Fibrous expansion of some
portal areas, with or without short fibrous septa
1
Fibrous expansion of most
portal areas, with or without short fibrous septa
2
Fibrous expansion of most
portal areas with occasional portal to portal (P-P) bridging
3
Fibrous expansion of portal
areas with marked bridging [portal to portal (P-P) as well as portal to
central (P-C)]
4
Marked bridging (P-P and/or
P-C) with occasional nodules (incomplete cirrhosis)
5
Cirrhosis, probable or definite 6
References

  1. Ishak K, et al. Histological grading and staging
    of chronic hepatitis.
    J Hepatol 1995;22:696-699.
  2. Knodell RG, et al. Formulation and application
    of a numerical scoring system for assessing histological activity in
    asymptomatic chronic active hepatitis. <ahref=
    “http://www.hepatitiscentral.com/hcv/liver/histologyindex.html”> Hepatology1981;1(5):431-5
*Additional features which¬†should be noted but not scored: Intra-acinar fibrosis, perivenular (‘chicken
wire’ fibrosis) and phlebosclerosis of terminal hepatic venules.