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Risk of Liver and Other Types of Cancer in Patients With Cirrhosis: A Nationwide Cohort Study in Denmark

Table  3.   Observed and Expected Numbers and SIR of Selected Cancer Sites in Different Types of Cirrhosis

Cancer Site
Alcoholic


Primary Biliary


Chronic Hepatitis


Nonspecified


Observed SIR 95% CI Observed SIR 95% CI Observed SIR 95% CI Observed SIR 95% CI

All malignant neoplasms
877 2.2 2.1-2.4 36 1.4 1.0-1.9 187 1.7 1.4-1.9 347 2.0 1.8-2.2
Liver (primary)
173 44.8 38.4-52.0 4 18.5 5.0-48.0 23 23.1 14.6-35.0 45 26.0 19.0-35.0
Hepatocellular carcinoma
142 70.6 59.5-83.2 4 47.0 12.6-120.2 18 42.7 25.2-67.3 35 43.4 30.3-60.4
Cholangiocarcinoma
17 15.3 8.9-24.5 0  ---  --- 0  ---  --- 4 7.2 1.9-18.3
Other and unspecified morphology
14 19.0 10.4-31.8 0  ---  --- 5 23.0 7.4-53.8 6 16.6 6.0-36.0
Tobacco-related sites
210 1.8 1.6-2.1 8 1.5 0.7-3.0 42 1.7 1.2-2.3 96 2.2 1.8-2.7
Lung
135 2.1 1.8-2.5 1 0.4 0.0-2.0 19 1.5 0.9-2.4 52 2.3 1.7-3.0
Urinary bladder
32 1.1 0.8-1.6 3 2.8 0.6-8.1 9 1.6 0.7-3.1 18 1.7 1.0-2.6
Kidney
26 2.2 1.5-3.3 2 3.0 0.3-10.7 8 2.7 1.1-5.3 9 1.8 0.8-3.5
Pancreas
17 1.6 0.9-2.6 2 2.6 0.3-9.5 6 1.8 0.7-3.9 17 3.1 1.8-5.0
Alcohol-related sites
193 9.6 8.3-11.0 1 1.4 0.0-7.6 13 3.5 1.9-6.0 34 5.1 3.5-7.1
Buccal cavity and pharynx
115 11.6 9.6-14.0 0  ---  --- 8 4.2 1.8-8.2 20 6.0 3.6-9.2
Esophagus
40 9.0 6.4-12.3 1 5.4 0.1-30 1 1.1 0.0-6.1 12 7.2 3.7-12.5
Larynx
38 6.5 4.6-9.0 0  ---  --- 4 4.7 1.3-11.9 2 1.2 0.1-4.3
Hormone-related sites*
81 1.3 1.0-1.6 5 0.7 0.2-1.7 20 0.8 0.5-1.2 45 1.4 1.0-1.8
Breast
44 1.6 1.2-2.2 4 0.9 0.3-2.4 11 0.7 0.4-1.3 24 1.4 0.9-2.1
Other sites, total*
220 1.1 1.0-1.3 18 1.5 0.9-2.3 89 1.6 1.3-2.0 127 1.4 1.2-1.7
Stomach
16 1.4 0.8-2.2 1 1.6 0.0-8.6 10 3.2 1.5-5.8 13 2.3 1.2-3.9
Colon
43 1.5 1.1-2.1 6 2.7 1.0-5.8 15 1.5 0.9-2.5 18 1.2 0.7-1.8
Nonmelanoma
60 1.1 0.8-1.4 2 0.6 0.1-2.0 25 1.6 1.0-2.3 33 1.3 0.9-1.8
Testis
5 2.2 0.8-5.1 0  ---  --- 2 2.7 0.0-9.9 1 2.2 0.0-12.4

NOTE. First year of follow-up excluded.
* Not all sites shown.

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