The latest research & treatment news about Hepatitis C infection, diagnosis, symptoms and treatment.

Mavyret (glecaprevir and pibrentasvir)

What is the dosage for Mavyret?

According to the manufacturer of Mavyret, there are various dosage regimens and durations.

Prior to treatment:

  • All patients should be tested for Hepatitis B virus infection by measuring HBsAg and anti-HBc.

Dosage regimens and durations:

  • Duration for treatment-na├»ve patients, Genotypes 1-6:
    • 8 weeks without cirrhosis
    • 12 weeks with compensated cirrhosis
  • Duration for treatment-experienced patients:
    • Genotype 1 – 16 weeks for patients with or without cirrhosis that were previously treated with a regimen containing an NS5A inhibitor without prior treatment with an NS3/4A protease inhibitor
    • Genotype 1 – 12 weeks for patients with or without cirrhosis that were previously treated with a regiment containing NS3/4A protease inhibitor without prior treatment with an NS5A inhibitor.
    • Genotypes 1, 2, 4, 5 or 6 – 8 weeks for patients without cirrhosis that were previously treated with a regimen that contained interferon, peginterferon, ribavirin, and/or sofosbuvir (PRS).
    • Genotypes 1, 2, 4, 5 or 6 – 12 weeks for patients with compensated cirrhosis that were previously treated with a regimen that contained PRS.
    • Genotype 3 – 16 weeks for patients without cirrhosis that were previously treated with a regimen that contained PRS.
    • Genotype 3 – 16 weeks for patients with compensated cirrhosis that were previously treated with a regimen that contained PRS.

Last Updated: October 2017

"FDA approves Mavyret for Hepatitis C." FDA.gov. U.S. Food & Drug Administration. https://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm570038.htm. Retrieved October 6, 2017.

"Highlights of Prescribing Information." Rxabbvie.com. AbbVie Inc., http://www.rxabbvie.com/pdf/mavyret_pi.pdf. Retrieved October 6, 2017.

"Mavyret Product Summary." Mavyret.com. AbbVie Inc., https://www.mavyret.com/content/dam/abbvie-mavyret-brand/product-summary.pdf. Retrieved October 6, 2017.

"Introducing MavyRet." Mavyret.com. AbbVie Inc., www.mavyret.com. Retrieved October 6, 2017.