Mavyret (glecaprevir and pibrentasvir)
When is Mavyret contraindicated?
Mavyret is contraindicated in patients with severe hepatic impairment. Additionally, Mavyret is contraindicated for use with atazanavir and rifampin.
The following chart provides information regarding additional medications that can have potential interactions with Mavyret. This table is not all inclusive.
|Drug Class||Specific Drugs Within Class Contraindicated with Mavyret|
|Ethinyl Estradiol-Containing Products||Ethinyl estradiol-containg medication such as combined oral contraceptives|
|Herbal Supplements||St. Johns’ wort (Hypericum perforatum)|
|HIV-Antiviral Agents||Atazanavir, Darunavir, Lopinavir, Ritonavir, Efavirenz|
|HMG-CoA Reductase Inhibitors||Atorvastatin, Lovastatin, Simvastatin, Pravastatin, Rosuvastatin, Fluvastatin, Pitavastatin|
Last Updated: October 2017
"FDA approves Mavyret for Hepatitis C." FDA.gov. U.S. Food & Drug Administration. https://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm570038.htm. Retrieved October 6, 2017.
"Highlights of Prescribing Information." Rxabbvie.com. AbbVie Inc., http://www.rxabbvie.com/pdf/mavyret_pi.pdf. Retrieved October 6, 2017.
"Mavyret Product Summary." Mavyret.com. AbbVie Inc., https://www.mavyret.com/content/dam/abbvie-mavyret-brand/product-summary.pdf. Retrieved October 6, 2017.
"Introducing MavyRet." Mavyret.com. AbbVie Inc., www.mavyret.com. Retrieved October 6, 2017.