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ABT-450 Shows Promising Results for Hepatitis C Patients

November 6, 2013

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A Phase 2b trial of ABT-450 (a once-a-day, all-oral drug regimen) revealed an average sustained virologic response of 95 percent in newly-diagnosed patients.

Trial data analysis shows Enanta’s hepatitis C drug is effective

November 4, 2013

By Don Seiffert
BioFlash Editor- Boston Business Journal

Enanta Pharmaceuticals’ partner on a potential drug for hepatitis C presented some promising early results from a mid-stage study of the drug over the weekend.

The Watertown biotech has developed a lead drug, a so-called protease inhibitor named ABT-450, which is part of a hepatitis C drug being tested by Abbott Laboratories. The once-a-day, all-oral drug regimen is notable in that it doesn’t contain interferon, which has been used in previous treatments for hepatitis C but causes flu-like side effects. Several companies are in the late stages of developing interferon-free drugs to treat the infectious liver disease that affects up to 200 million people worldwide. Abbott gave results of a Phase 2b trial of the drug on Sunday at the annual meeting of the American Association for the Study of Liver Diseases in Washington.

Continue reading this entire article:
http://www.bizjournals.com/boston/blog/bioflash/2013/11/trial-data-so-far-shows-enantas.html

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HepatitisCentral.com provides information regarding hepatitis and liver disease. Comments are available to the community in order to discuss these topics and obtain answers to questions through community members. The Editors at HepatitisCentral.com will not be responding to questions or comments posed in article comments.

  • s

    Newly diagnosed what about those had treatment and the virus failed and more antibodies in the system after treatment

  • angle

    I went to see if I could start the Once a day pill but I had the first treatment years ago so I couldn’t be in the trail

  • Jay Cee

    Who do I contact about participating in clinical trial of this new Hep-C drug?

    • fulvio

      how can we participate .did u get a reply

  • jtip

    yes who do i contact to participate in this study

  • rence well

    Ask your doctor how to get enrolled in a trial. Maybe start there.

  • rence well

    Keep in mind that when participating in a trial some poor schmuck has to receive the dreaded placebo though.

  • sanj

    who do i contact about participating in clinical trial of this drug.

  • lev

    the drug brought about an average sustained virologic response of 95 percent in newly-diagnosed patients and 90 percent in the others!!!!

  • kaizer

    When will these drugs be availible ? We have been waiting for the last ten years now .

  • BarbaraT

    isn’t this old news?

  • BarbaraT

    FDA is suppose to vote Dec. 7 2013

  • Paul M

    I am a 1a genotype non responder. I have completed 2 full rounds (48 weeks) of the Interferon/Ribavarin therapy (years apart, initially promising, but viral levels never “undetectable”.) Had Round 3 with Vertex’s protease inhibitor then interferon/ribavarin, undetectable!, for 1 month following cessation of treatment, then virrus re-appeared. Does anyone have any information on cases like mine? This treatment is being touted for “newly diagnosed” patients, no pre-exsisting condition mentioned?

    • guest

      Paul, keep in touch please. Sounds like my husband has the exact same history with this virus. Was taken off his second round of treatment with the added pill Victrellis/Boceprevir. Could not achieve a SVR. Originally did treatment many years ago with Interferon and Ribivarin, but didn’t achieve SVR. He started symptoms again many years later.(mainly itching and insomnia) so he tried the drug above. He is Genotype 1b. Waiting for the newer drugs which are supposed to help cure the relaspers/non responders. His recent liver scan is showing a compensated liver with early cirrhosis. We are hoping the new drugs will cure him. More and more baby boomers are now being diagnosed. He is a Vietnam Veteran. Good luck to you!