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Discovery of Genetic Protein that Impacts Hepatitis C Recovery

January 9, 2013

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Genetic scientists at the National Institutes of Health have recently found a variant on chromosome 19 that interferes with successful Hepatitis C treatment – a discovery that could lead to better understanding and management of this virus.

Hepatitis-C Virus Treatment Affected By Newly Discovered Gene Mutation: NIH

Added by GM on January 7, 2013.

The National Institutes of Health, (NIH), a division of the U.S. Department of Health and Human Services (HHS), announced in a press release dated 1/6/2013 that scientists from the National Cancer Institute (NCI) have discovered a gene mutation that affects the treatment of the Hepatitis C virus.

Scientists have discovered a gene that interferes with the clearance of hepatitis C virus infection. They also identified an inherited variant within this gene, Interferon Lambda 4 (IFNL4), that predicts how people respond to treatment for hepatitis C infection. The results of this study, by investigators at the National Cancer Institute (NCI), part of the NIH, and their collaborators at NIH and other institutions, were published online in Nature Genetics on Jan. 6, 2013.

Continue reading this entire article:
http://guardianlv.com/2013/01/hepatitis-c-virus-treatment-affected-by-newly-discovered-gene-mutation-nih/

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  • Merry

    I found out last month, after having submitted to the IFN test mentioned in this article, that I am one of many who will unlikely benefit from the current SOC, with Interferon therapy. I particitipated in Gilead’s most recent trial of GS7977? taken with Ribavirin. My viral load dropped to undectectable levels after 3 weeks and remained undectable until end of my 3 month treatment. Unfortunately, one month later the returned hence treatment had been unsuccessful. I have not given up hope. I am waiting to repeat a non-interferon based treatment with longer treatment duration protocols, as soon as the FDA approves Gilead’s study drug, which should be before the end of 2013! Yay! I have Hep C genotype 3 with compensated cirrohsis.
    Be well my fellow Heppers!

    • gary

      Hi Merry,
      my name is Gary..I have the same genotype with mild cirrohsis.My viral lode is down to 80. I take my sixth shot today.I am thinking that the virus will be undetectable by week 7..I have been asked to continue treatment for at least 6 months..There are days that I feel fine and other days that become challenging.I am also doing 600 milligram ribavirin twice a day.

  • trotter

    You guys are both doing well. Any of the treatments are very tough and a lot of people drop out because of the side affects. Be sure to keep doing it for as long as they suggest. If u add on a bit, it will pay off in the end. You are fortunate (a bit) in having genotype 3, it is easier to get it in remission and keep it. I know three people that are genotype 2, they were able to be on tx 6 months (1A usually 1 yr.) and were in remission. Only one of them had their Hep C come back, after 7 years. Most of the 1As I know did not go in remission, did tx again,etc. You don’t have it easy for sure, but a little easier. You’ve got the odds on your side. Good luck. Be proud of yourselves. Get tested as often as doctor says. Then, go out a live – may be a bit slower – but you’ll live it looks like. I’ll be thinking of you..