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Hepatitis C Protein Interaction Identified

January 5, 2011

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Scripps researchers have identified a protein that interacts with the Hepatitis C virus to enable replication. Since blocking this interaction could impair the virus’ ability to reproduce, Scripps’ discovery could lead to a new focus for the next generation of Hepatitis C drugs.

Scripps Research scientists identify key interaction in hepatitis C virus

Findings point toward a novel therapeutic target for antiviral drugs

JUPITER, FL, December 28, 2010 – Scientists from the Florida campus of The Scripps Research Institute have identified a molecular interaction between a structural hepatitis C virus protein (HCV) and a protein critical to viral replication. This new finding strongly suggests a novel method of inhibiting the production of the virus and a potential new therapeutic target for hepatitis C drug development.

The study was published in the January 2010 issue (Volume 92, Part 1) of the Journal of General Virology.

These new data underline the essential role of the viral protein known as “core” as a primary organizer of the infectious HCV particle assembly and support a new molecular understanding of the formation of the viral particle itself.

Continue reading this entire article:
http://www.eurekalert.org/pub_releases/2010-12/sri-srs122810.php

Contact: Mika Ono
[email protected]
858-784-2052
Scripps Research Institute

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