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Novel Hep C Strategy Aimed at Host Cells

October 19, 2012

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An Israeli company has a drug in development with a unique approach for fighting Hepatitis C – targeting the host cell instead of the virus itself.

A New And Interesting Addition To The Hep C Clinical Pipeline

October 17, 2012

The race towards an interferon-free hepatitis C treatment continues to heat up, with a newcomer to the clinical pipeline – BioLine Rx’s (BLRX) BL-8020. The Israeli company, which in-licensed the drug earlier this year, announced that it had successfully completed the pre-clinical development of the anti Hep C drug, and that a phase I/II is planned to begin in Europe during the first quarter of 2013.

Unlike the vast majority of Hep C drugs under development, BL-8020 is not a protease or polymerase inhibitor. In fact, this drug doesn’t directly target the hepatitis virus at all, but instead, targets the host cell. BL-8020 inhibits a naturally occurring mechanism in the cell termed “autophagy”, which is used by the hepatitis C (and other viruses) for its replication process. This unique mechanism of action provides BioLine’s drug with several advantages:

Continue reading this entire article:
http://seekingalpha.com/article/929921-a-new-and-interesting-addition-to-the-hep-c-clinical-pipeline

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  • jeff

    May this be God’s messengers to find a cure for Hep C. I wish I could start a clinical trial in 2013.