The latest research & treatment news about Hepatitis C infection, diagnosis, symptoms and treatment.

Previous

7 Ways Hepatitis C Affects Women Differently than Men

Back to News Homepage

Next

Racing to Shorten Duration of Hep C Treatment

Phase I Clinical Trial for Hepatitis C Drug Starts: ACH-3422

June 12, 2014

Print this page

Find out about a new phase I clinical trial that Achillion Pharmaceuticals Inc. has initiated for its Hepatitis C drug candidate, ACH-3422.

Achillion Pharmaceuticals Inc. announced the company has begun dosing ACH-3422, a uridine-analog nucleotide polymerase inhibitor, for seven days in patients with genotype 1 chronic hepatitis C viral infection (HCV) in its ongoing Phase 1 clinical trial. Proof-of-concept results from this trial are expected to be reported during the fall of 2014. Furthermore, Achillion announced that the U.S. Food and Drug Administration (FDA) has removed the clinical hold on sovaprevir, an NS3/4A protease inhibitor, to permit the conduct of trials in patients with HCV. Sovaprevir doses of 200 mg once daily, the previously evaluated dose that was well-tolerated with clinical activity in two completed Phase 2 studies, may be used in additional therapeutic clinical trials.

Continue reading this entire article:
http://www.dddmag.com/news/2014/06/achillion-kicks-phase-1-trial-hep-c-drug

7 Comments
Share
Share

Previous

7 Ways Hepatitis C Affects Women Differently than Men

Back to News Homepage

Next

Racing to Shorten Duration of Hep C Treatment

Requirements for using and reposting articles

Comments

HepatitisCentral.com provides information regarding hepatitis and liver disease. Comments are available to the community in order to discuss these topics and obtain answers to questions through community members. The Editors at HepatitisCentral.com will not be responding to questions or comments posed in article comments.

  • Tim

    Where I can find clinical trial for hepatitis drugs ach 3422 in MD I have HVC 1b.Thank you

    • Gia A Hopkins

      Hi,
      I am from Florida but flew up to John Hopkins to screen for study they are always running studies , you have to call alot get your name in their head. it took me 4 1/2 years to get help I was in stage 4 liver failure and had been all over, funny thing A Doctor I did old treatment intaferon 3 combo 2 times with no success. Don’t give up ever I got into a study with the Doctor I did 2 other treatments with on my last week have been 0 viral load since week 8 1 pill very minimum side effects the drug is a combo pill Sofosbuvir/ledipasvir. I believe this drug will be out soon kills the dam virus feeling better already I still am in dis belief this nightmare might be over it is awesome. I seriously thought this hepc was going to kill me I am 1A genotype. BUG THESE STUDYS if they know you are serious your chances a far better wish you the best!!!

      • Razor

        I have been suffering with the damn virus for yrs! Did interferon and it mutated! How can I get involved with Johns Hopkins like you did, Gia??

        • Gia A Hopkins

          Hi Razor,
          Call John Hopkins or google John Hopkins studies. and also google hep c studies in my area a zip code prompt should come up, and they will give you a list call alot bother them lol I did!! If all else fails write the Drug company;s Gilead drugs has new combo drug I took ask them to sponser you and most of all don’t give up I was a dead woman until 4 months ago. God Bless

      • grits

        good to hear your success. did you have bleeding varices? and fluid build up in the stomach.
        I have been to the hospital bleeding out five times but they gave me blood and more treatment to control the bleeding. on the edge of tips procedure?
        has the liver recovered since 0 hcv?

        • Gia A Hopkins

          no I did not have bleeding varacies but I have a partner who has hep B and he had bleeding varices it was scary 3 bleedouts and blood transfusions scary indeed. The Doctors fixed his throught with a procedure since then has has been much better. I had alot of water retention to the point i felt like a stuffed sausage that is all going away. I just finished study go back in 2 months for recheck they told me this was a cure the only way it could come back is if I got re infected, Praying they are right i don’t know how I would take another flop treatment but I have nothing but positive feelings because my water is going away puffiness is going away kidneys functioning better already. I believe it is gone forever keep you all posted and in my prayers !!

    • MindFury

      There is a website https://clinicaltrials.gov/ct2/results?term=Hep+c&Search=Search. they have trials listed all the times.