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Promising Partnership in Treating Hepatitis C

October 24, 2006

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Two leading companies are merging in an effort to accelerate Hepatitis C treatments. The goal of this collaboration is to further the development of Hepatitis C protease inhibitors.

Roche and InterMune to develop hepatitis C products

Pharmaceutical Business Review Online
By Victoria Harrison

Roche and InterMune have signed an agreement to develop and commercialize candidates from InterMune’s hepatitis C protease inhibitor program
The agreement includes InterMune’s lead compound ITMN-191, which is expected to enter clinical trials before the end of the year. The companies will also collaborate on a research program of novel second-generation hepatitis C protease inhibitors.

“We believe this partnership will help accelerate the development of ITMN-191 and future second-generation protease inhibitors,” said Dan Welch, CEO of InterMune.
Roche will exclusively license ITMN-191 and will have the right to exclusively license further hepatitis C protease inhibitor development candidates resulting from the research collaboration.

InterMune will conduct phase I studies of ITMN-191, and thereafter Roche will lead clinical development and commercialization. Upon closing, InterMune will receive from Roche an upfront payment of $60 million. InterMune could potentially receive up to $470 million in milestones as a result of the deal. The companies will co-commercialize the product in the US.

The economic terms for ITMN-191 could also apply to additional compounds that InterMune and Roche develop.

The transaction will close following the expiration or early termination of an antitrust regulatory waiting period.

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