The latest research & treatment news about Hepatitis C infection, diagnosis, symptoms and treatment.

Viekira Pak™ (ombitasvir, paritaprevir, and ritonavir tablets; dasabuvir tablets)

When is Viekira Pak™ contraindicated?

You should not take Viekira Pak™ if you have severe hepatic impairment (due to risk of potential toxicity).

Generally, Viekira Pak™ should not be taken with medicines that are:

  • highly dependent on CYP3A clearance.
  • strong inducers of CYP3A and CYP2C8.
  • strong inhibitors of CYP2C8.

The following chart provides information regarding drugs that are contraindicated with Viekira Pak™ (the table is not all-inclusive). (For more information regarding the effect of co-administration of these medications with Viekira Pak™ please visit


Drug Class Specific Drugs Within Class Contraindicated with Harvoni®
Alpha1-Adrenoreceptor Antagonists Alfuzosin HCL
Anticonvulsants Carbamazepine
Antihyperlipidemic Agents Gemfibrozil
Antimycobacterials Rifampin
Ergot Derivatives Ergotamine
Ethinyl Estradiol-Containing Products Such as combined oral contraceptives
Herbal Products St. Johns’ wort (Hypericum perforatum)
HMG-CoA Reductase Inhibitors Lovastatin
Neuroleptics Pimozide
Non-Nucleoside Reverse Transcriptase Inhibitors Efavirenz
Phosphodiesterase-5 (PDE5) Inhibitors Sildenafil when dosed as Revatio for the treatment of pulmonary arterial hypertension (PAH)
Sedatives/Hypnotics Triazolam
Orally administered midazolam


For those that have a known hypersensitivity to ritonavir, Viekira Pak™ is contraindicated.

Last Updated: May 2015

Advances in Medications to Treat Hepatitis C., American Liver Foundation. Retrieved May 7, 2015.

Benefits Verification., Retrieved May 7, 2015.

FDA Approves Viekira Pak to Treat Hepatitis C., U.S. Food and Drug Administration. Retrieved May 7, 2015.

Highlights of Prescribing Information - Viekira Pak., AbbVie, Inc. Retrieved May 7, 2015.

proCeed Support Program., Retrieved May 7, 2015.

Viekira Pak (ombitasvir/paritaprevir/ritonavir tablets; dasabuvir tablets)., Retrieved May 7, 2015.