Hepatitis C, Association of Diabetes Mellitus and Chronic Hepatitis C Virus Infection

Association of Diabetes Mellitus and Chronic Hepatitis C Virus Infection

table 1. Characteristics of All Patients in the Chronic Viral Hepatitis Cohort

Clinical Features	Virological Diagnosis (%)		P
Clinical Features	HBV^* (N = 486)	HCV^* (N = 604)	P

Age (yr)
37	106 (28)	88 (15)	<.0001
37-43	68 (18)	122 (21)
43-49	74 (19.5)	117 (20)
49-61	74 (19.5)	120 (20)
>61	57 (15)	135 (23)
Sex
Female	108 (22)	218 (36)	<.0001
Male	375 (78)	386 (64)
Race origin
White	301 (70)	481 (81)	<.0001
African	82 (19)	93 (16)
Hispanic	7 (2)	10 (2)
Asian	38 (9)	6 (1)
Cirrhosis	88 (38)	145 (41)	.51
Noncirrhotic	144 (62)	212 (59)
Study criteria
(i) Exclusion	87 (18)	109 (18)	1.0
(ii) Diabetes	64 (13)	145 (24)	<.0001
(iii) Diabetics excluded	16 (18)	37 (34)	.015

NOTE. (i) Conditions predisposing to hyperglycemia: hemochromatosis (n = 3), chronic pancreatitis (n = 2), carcinoma of pancreas (n = 1), total parenteral nutrition (n = 6), corticosteroid (n = 179), and hydrochlorothiazide therapy (n = 10). (ii) Use of oral hypoglycemic medication or insulin, random glucose 200 mg/dL, fasting glucose 140 mg/dL on two occasions, or attending an endocrine clinic for diabetes. (iii) Diabetics excluded from final analysis (% = patients in [iii] divided by [i] × 100). ^* Twenty-seven patients with both chronic HBV and HCV infection were omitted from this table . The discrepancy in numbers compared with total population size is due to records without data. Cirrhosis established by liver biopsy (n = 207) or presumptive diagnosis made on clinical grounds (n = 35) and diagnosis of noncirrhotic by liver biopsy (n = 367).