Damage Scores for Liver Biopsy
|HISTOLOGY ACTIVITY INDEX (HAI - Knodell Score)||
|Periportal ± Bridging Necrosis||Score||Intralobular Degeneration and Focal Necrosis||Score||Portal Inflammation||Score||Fibrosis||Score|
|None||0||None||0||No portal inflammation||0||No fibrosis||0|
|Mild piecemeal necrosis||1||Mild (acidophilic bodies, ballooning degeneration and/or scattered foci of hepatocellular necrosis in 1/3 of lobules or nodules)||1||Mild (sprinkling of inflammatory cells in 1/3 of portal tracts)||1||Fibrous portal expansion||1|
|Moderate piecemeal necrosis (involves 50% of the circumference of most portal tracts)||3||Moderate (involvement of 1/3-2/3 of lobules or nodules)||3||Moderate (increased inflammatory cells in 1/3-2/3 of portal tracts)||3||Bridging Fibrosis (portal-portal or portal-central linkage)||3|
|Marked piecemeal necrosis (involves 50% of the circumference of most portal tracts)||4||Marked (involvement of 2/3 of lobules or nodules)||4||Marked (dense packing of inflammatory cells in 2/3 of portal tracts)||4||Cirrhosis||4|
|Moderate piecemeal necrosis plus bridging necrosis||5||
ReferenceKnodell RG, et al.
|Marked piecemeal necrosis plus bridging necrosis||6|
Some of our most commonly asked questions and our answers to them.
Learn about the Hepatitis C Virus (HCV).
Information about the transmission of Hepatitis C.
You'll find links to a comprehensive symptoms list, as well as various studies and discussions about Hepatitis C symptoms.
Learn about the conventional medical treatments used to fight Hepatitis C.
Numerous links to studies, info sheets, FAQs, and analysis of Ribavirin/Rebetron medicines.
Alternative methods of treatment due to side effects and dissatisfication with current medical treatments.
A number of herbal products useful in the management of liver disease.
Receive the latest news on hepatitis treatments, clinical trials, social issues and important breakthroughs.
Learn about Hepatitis C Genotypes and their variants.
A state-by-state and worldwide reference listing physicians who treat HCV, including an email link to submit your physician for inclusion.
Convenient links to other sites external to Hepatitis-Central.
A Bulletin Board for discussions on hepatitis, treatments, etc.
An easy way to get involved in urging our government to do more for Hepatitis C awareness and treatment research.
Numerous links to various Hepatitis B related information, including transmission, symptoms and treatment.
A comprehensive resource of information relating to the liver biopsy.
Many discussions and analyses of cirrhosis, including causes, complications, pathology, symptoms, and much more.
Commonly used medical terms and definitions.
What they are and what they mean. Helps you interpret & understand all the various hepatitis lab tests likely to be encountered.
Liver Cancer/Hepatocellular Carcinoma studies, info sheets, FAQs, and analysis.
An exhaustive list of links to studies, info sheets, FAQs, and analysis of the various drugs used to treat liver disease.
Provides information regarding the best known liver supporting supplements.
Provides information regarding the best known milk thistle supplements.
Provides detailed information on how to analyze and interpret viral load numbers as well as a link to a convenient Viral Load Chart.
Learn more about various Hepatitis C related topics, including HCV, Ascites, Biopsies, and much more.
Recommended reading for those interested in hepatitis information.