Damage Scores for Liver Biopsy
|HISTOLOGY ACTIVITY INDEX (HAI - Knodell Score)||
|Periportal ± Bridging Necrosis||Score||Intralobular Degeneration and Focal Necrosis||Score||Portal Inflammation||Score||Fibrosis||Score|
|None||0||None||0||No portal inflammation||0||No fibrosis||0|
|Mild piecemeal necrosis||1||Mild (acidophilic bodies, ballooning degeneration and/or scattered foci of hepatocellular necrosis in 1/3 of lobules or nodules)||1||Mild (sprinkling of inflammatory cells in 1/3 of portal tracts)||1||Fibrous portal expansion||1|
|Moderate piecemeal necrosis (involves 50% of the circumference of most portal tracts)||3||Moderate (involvement of 1/3-2/3 of lobules or nodules)||3||Moderate (increased inflammatory cells in 1/3-2/3 of portal tracts)||3||Bridging Fibrosis (portal-portal or portal-central linkage)||3|
|Marked piecemeal necrosis (involves 50% of the circumference of most portal tracts)||4||Marked (involvement of 2/3 of lobules or nodules)||4||Marked (dense packing of inflammatory cells in 2/3 of portal tracts)||4||Cirrhosis||4|
|Moderate piecemeal necrosis plus bridging necrosis||5||
ReferenceKnodell RG, et al.
|Marked piecemeal necrosis plus bridging necrosis||6|
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