Hepatitis Central

The latest research & treatment news about Hepatitis C infection, diagnosis, symptoms and treatments.

Damage Scores for Liver Biopsy

Less Than Less Than

Greater Than More Than

HISTOLOGY ACTIVITY INDEX (HAI - Knodell Score)

 

Periportal ± Bridging Necrosis Score Intralobular Degeneration and Focal Necrosis Score Portal Inflammation Score Fibrosis Score
None 0 None 0 No portal inflammation 0 No fibrosis 0
Mild piecemeal necrosis 1 Mild (acidophilic bodies, ballooning degeneration and/or scattered foci of hepatocellular necrosis in 1/3 of lobules or nodules) 1 Mild (sprinkling of inflammatory cells in Less Than 1/3 of portal tracts) 1 Fibrous portal expansion 1
Moderate piecemeal necrosis (involves      Less Than 50% of the circumference of most portal tracts) 3 Moderate (involvement of 1/3-2/3 of lobules or nodules) 3 Moderate (increased inflammatory cells in 1/3-2/3 of portal tracts) 3 Bridging Fibrosis (portal-portal or portal-central linkage) 3
Marked piecemeal necrosis (involves     Greater Than 50% of the circumference of most portal tracts) 4 Marked (involvement of Greater Than 2/3 of lobules or nodules) 4 Marked (dense packing of inflammatory cells in Greater Than 2/3 of portal tracts) 4 Cirrhosis 4
Moderate piecemeal necrosis plus bridging necrosis 5

ReferenceKnodell RG, et al. 

Marked piecemeal necrosis plus bridging necrosis 6
Multilobular necrosis 10

Site Topics

  • Frequently Asked Questions

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  • Hepatitis News

    Tthe latest news on hepatitis treatments, clinical trials, social issues and important breakthroughs.

  • What Is Hepatitis C?

    Learn about the Hepatitis C Virus (HCV).

  • Hepatitis C Symptoms

    You'll find links to a comprehensive symptoms list, as well as various studies and discussions about Hepatitis C symptoms.

  • Hepatitis C Transmission

    Information about the transmission of Hepatitis C.

  • Hepatitis C Genotypes

  • Learn about Hepatitis C Genotypes and their variants.

  • HCV Viral Load

    Provides detailed information on how to analyze and interpret viral load numbers as well as a link to a convenient Viral Load Chart.

  • Liver Enzymes

    Learn about the importance of testing liver enzyme levels and causes of abnormal levels.

  • Lab Tests

    What they are and what they mean. Helps you interpret & understand all the various hepatitis lab tests likely to be encountered.

  • Hepatitis During Pregnancy

    Learn how hepatitis infection may affect the pregnant mother and baby.

  • Hepatitis C Conventional Treatment

    Learn about the conventional medical treatments used to fight Hepatitis C.

  • Hepatitis C Medicines

    Numerous links to studies, info sheets, FAQs, and analysis of Ribavirin/Rebetron medicines.

  • Hepatitis C Alternative Therapies

    Alternative methods of treatment due to side effects and dissatisfication with current medical treatments.

  • Hepatitis C Natural Remedies

    A number of herbal products useful in the management of liver disease.

  • Top 5 Liver Supplements

    Provides information regarding the best known liver supporting supplements.

  • Top 5 Milk Thistles

    Provides information regarding the best known milk thistle supplements.

  • HCV Diet

    A basic diet for those with Hepatitis C.

  • Hepatitis C Survivor Stories

    Survivor stories that have been shared to benefit others with Hepatitis C.

  • Cirrhosis

    Many discussions and analyses of cirrhosis, including causes, complications, pathology, symptoms, and much more.

  • Hepatitis C Doctors

    A state-by-state and worldwide reference listing physicians who treat HCV, including an email link to submit your physician for inclusion.

  • Hepatitis C Community External link

    A Bulletin Board for discussions on hepatitis, treatments, etc.

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