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10 Facts Impacting Chronic Hepatitis B Treatment

Nicole Cutler L.Ac. March 24, 2011

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The variables associated with Hepatitis B and the drugs used to treat it demonstrate that there is no single, uniform treatment strategy for addressing chronic Hepatitis B infection.

For the millions of people infected with chronic Hepatitis B, there is no one standard treatment route. Each with its own strengths and drawbacks, choosing which Hepatitis B medication is best – if any at all – is a complex process. If you or someone you love is wondering how to best contend with chronic Hepatitis B infection, make sure you are aware of these 10 facts that could play a major role in how this illness is approached.

About Chronic Hepatitis B

When the virus continues to multiply in the body for more than six months, a person has chronic Hepatitis B infection. Although most people with chronic Hepatitis B have no symptoms, they can still pass the virus to others – especially to people they live with or have sex with. People with chronic Hepatitis B are at increased risk of chronic hepatitis, which can lead to complications such as cirrhosis, liver cancer, liver failure and death.

According to the World Health Organization, more than 2 billion people living today have been infected with Hepatitis B at some time in their life. Of these, about 350 million remain chronically infected and become carriers of the virus. Thus, effective Hepatitis B treatments are in high demand. However, deciding whether or not to treat chronic Hepatitis B and how to treat it can be a confusing and overwhelming journey. To help understand more about experts’ suggestions and the options available, 10 facts about chronic Hepatitis B treatment are listed below:

  1. Because antiviral agents, the best therapy known for chronic Hepatitis B, do not work in everyone with the virus, all people with chronic Hepatitis B do not necessarily need to be on medication.
  2. According to the American Association for the Study of Liver Disease (AASLD), those with chronic Hepatitis B are advised to take antiviral therapy if they have high levels of Hepatitis B virus DNA in the blood AND have either high levels of liver enzymes or liver disease.
  3. All of the medications currently used to treat chronic Hepatitis B are antiviral drugs that reduce the ability of the virus to reproduce in the body and give the liver a chance to heal itself. These drugs are not a cure for Hepatitis B, but they do reduce the damage caused by the virus.
  4. Although not recommended for those who have cirrhosis or who have had a liver transplant, interferon stops Hepatitis B viral growth in about 35 percent of people who take it. The side effects of this medicine can be severe.
  5. Only used for chronic Hepatitis B treatment since 2005, studies suggest that another form of interferon with less frequent dosing – pegylated interferon – works better at stopping the Hepatitis B virus than lamivudine.
  6. Nucleoside/nucleotide analogues (NAs) block the Hepatitis B virus from making new viral particles. Higher treatment success rates are achieved in people who do not have “Hepatitis B e antigen” – which indicates if the virus is actively multiplying.
  7. Despite drug resistance typically developing within one year, the NA drug, lamivudin, can be used by those with cirrhosis or a weak immune system. Lamivudine reduces liver damage in about half of the people who use it without causing many side effects.
  8. Also reducing liver damage in about half of the people who use it without many side effects, adefovir is an NA that poses less of a problem of drug resistance than lamivudine. However, adefovir can harm the kidneys and make HIV medicines less effective. In addition, stopping adefovir treatment can cause liver enzymes to rebound to high levels – prohibiting some to ever stop taking this drug.
  9. Shown to be more effective than lamivudine, entecavir is an NA that greatly reduces liver inflammation and scarring. However, entecavir is associated with some unpleasant side effects and its long-term effects are not yet known.
  10. Approved for use in 2006, telbivudine is another NA that appears to be more effective than lamivudine, as well as more expensive. Besides not knowing about its long-term effects, this relatively new Hepatitis B drug may have drug resistance problems similar to lamivudine.

Whether considering foregoing pharmaceutical treatment, taking an interferon-based drug regimen or a nucleoside/nucleotide analogue, there are many options for addressing chronic Hepatitis B. Typically reserved for people whose infection is likely to progress to active hepatitis or cirrhosis, antiviral therapy is not appropriate for everyone with this virus. For those who are candidates for taking antiviral medication, picking a chronic Hepatitis B therapy must be carefully chosen under the guidance of a knowledgeable physician.

References:, Hepatitis B, Retrieved February 18, 2011, WebMD, Inc. 2011., Hepatitis B Treatment Information, Retrieved February 18, 2011, Hepatitis B Foundation, 2011., Should I use antiviral therapy for chronic hepatitis B?, Retrieved February 16, 2011, WebMD, LLC, 2011., Hepatitis B, Retrieved February 19, 2011, World Health Organization, 2011.



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Comments provides information regarding hepatitis and liver disease. Comments are available to the community in order to discuss these topics and obtain answers to questions through community members. The Editors at will not be responding to questions or comments posed in article comments.

  • Orewele Goodluck

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  • Judge Benard

    I’m judge benard from switzerland, I was diagnosed of Hep B in 2009, and my Liver was bad. I saw a post about Dr. Asein Herbs that cures HIV, HEPATITIS B, DIABETES, CANCER, HERPES, and lots more…. I contacted him and told him about my health, he asked me not to worry anymore that he’s going to prepare the medicine and send it to me in my country. 3 days after sending the medicine I received the package and I took the medicine as prescribed by him and I was cured from Hepatitis B Virus. I took the medicine for 14 days,and the medicine has no Negative Influence, it only helped me get cured. Contact him via [email protected] or you whatsapp him on +2348163904713,or you contact me on [email protected]…………………….

  • linda

    I was diagnosed of hepatitis b in 2014 and I tried all possible means to get cure but all to no avail until i saw a post in a health forum about a herbal doctor from South Africa who prepare herbal medicine to cure all kind of diseases including hepatitis b virus, at first i doubted if it was real but decided to give it a try, when i contact this herbal doctor via his email i bought the hepatitis b herbal medicine and received it through DHL within 7 days and used it as prescribed, i tested negative to hepatitis b virus within 3 weeks of usage. Contact this great herbal doctor via his email ejiroherbalcure(at)gmail(dot)com or call +27617403481 (Please write email in right format)

  • Anymous

    Greetings to the general public, i want to tell the hole world about how i was cured of hepatitis b disease by a man called Dr Oyekpen. i have spend a lot of dollars of medication and there was no solution, I was browsing through the Internet searching for remedy on (hepatitis b disease) and i saw a comment of people talking about how Doctor Oyekpen cured them with herbal medication. I Was scared because i never believed in the Internet but i was convince to give him a try because i was having no hope of been cured of hepatitis b disease so i decided to contact him with his email that was listed on the comment ([email protected] ) when i contacted him he gave me hope and send a Herbal medicine to me that i took and it seriously worked for me, am a free person now without problem, my hepatitis b result came out negative. I pray for you Dr Oyekpen God will give you everlasting life, you shall not die before your time for being a sincere and grate men. Am so happy, you can also contact him if you are also suffering from any deadly disease Email: [email protected] or call him tel: +2348168257144 Goodluck.

  • lindamarcia

    I am Linda from USA, I can’t believe how Dr
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  • Geeta Kamar

    I want to thank Dr Osele for the herbal medicine he gave to me and my brother , i and my sister have been suffering from chronic Hepatitis B for the past 10years and ever since we were infected with this disease,we have been in tears everyday, but to God be the glory that we are both heal with the herbal medicine that Dr Osele gave to me and my brother when i contacted him,i want to use this medium to tell everyone that the solution to every of our disease has come, so i will like you to contact this great healer who live in South Africa, on his email address: healthmedicallab(at)gmailcom, with him all your pains and troubles will be gone, i am really happy today that i and my sister are cured of chronic Hepatitis B, we are now negative after the use of his medicine,my doctor confirm it. once more i say a big thank to you Dr Osele for his healing hands upon my life and my sister, he has all the cure to all manner of diseases like HIV, Cancer, Syphilis, Hepatitis B all types of cancer (HPV) , Gonorrhea, Diabetes,herpes and many more, i say may God continue to bless you abundantly and give you more power to keep helping those that want your help in their lives. contact his Email: healthmedicallab(at)gmailcom

  • Geeta Kamar

    Is there any permanent cure or treatment for chronic/acute HbsAg (Hepatitis B)positive patients? yes, email Dr Osele [email protected] whatsapp no. +27846531636

  • Manish Gautam

    i am Manish Gautam, i live in Guwahati india, September 2015 I learned my HBsAg was reactive when I was required to undergo medical exam for an employment in Broad, and the doctor told me there is no permanent cure for the disease, I was worried and confused thougth my life has come to an end, in december i came across a forum, (MED LAB) WHo cured all kind of diseases including hepatitis b, I contacted them via email medlab36(at)gmailcom and made purchase of the hepatitis Vaccine, i received the Vaccine thorugh DHL within 3 days, when i received the Vaccine i applied it as prescribed and i was totally cured of hepatitis b within fews days of usages, i went back to my doctor and he confirmed i was free curable cured from the disease, am so happy now living a normal life again thanks to MED LAB. VIewers contact MED LAB via email: medlab36(at)gmailcom