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Sofosbuvir Meets Goals in Hepatitis C Trials

February 11, 2013

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Inching closer to finding a successful interferon-free treatment for Hepatitis C, Gilead’s Neutrino and Fission trials posted encouraging results for the drug, sofosbuvir.

Gilead’s two hepatitis C drug trials meet study goals

(Reuters) – Biotechnology company Gilead Sciences on Monday said two trials of its hepatitis C drug, the centerpiece of its oral hepatitis C treatment program, met their goals in two late-stage studies.

The results are expected to be used to support the company’s regulatory filing seeking approval in the United States. Industry analysts say the market for such drugs could reach $25 billion by 2020.

An estimated 4 million Americans have the virus, with 170 million infected worldwide.

Gilead’s hepatitis C drugs program is considered among the most advanced of many companies racing to bring an interferon-free treatment regimen to market. The newer hepatitis C drugs, while doubling the cure rate of prior treatments, must still be taken with interferon, which causes miserable flu-like symptoms that lead many patients to discontinue or put off treatment.

Continue reading this entire article:
http://health.yahoo.net/news/s/nm/gilead-s-two-hepatitis-c-drug-trials-meet-study-goals

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HepatitisCentral.com provides information regarding hepatitis and liver disease. Comments are available to the community in order to discuss these topics and obtain answers to questions through community members. The Editors at HepatitisCentral.com will not be responding to questions or comments posed in article comments.

  • Kevin

    I’m taking the Bristol Myer Squibbs all oral treatment. I went undetectable in 11 days; zero side effects. I feel fantastic. When I had Hep C, I was always exhausted and my muscles ached. My legs ached so bad I had difficulty getting out of the car. Well, the virus is gone and so are the fatigue and achy muscles. I feel great. Just hang in everyone. The research company where I’m getting the drugs tell me that hopefully the drugs will be released later this year or early next year. If you can, try to get into a study. One is going on in Miami they’re still take new candidates. Miami Research Associates, 305 598 3125.

    • Cathy

      That’s wonderful news! So happy for you Kevin! I am hoping something comes on the market soon to cure me as I have a young son. I tried viramidine and interferon clinical trial 10 years ago but no success 🙁 You give me new hope! It will prob take longer to become available in the UK though I’d imagine!
      Did you have chronic Hep C and genotype 1?

      Cathy x

      • SuziQ

        Gilead is doing a study in UK shortly. Look them up on clinical trials. NO interferon–not sure if they take those who are not treatment naïve–but check it out.

    • deb

      what is Bristol Myer Squibbs i have hepc geno 1 chronic i just got dignosed 1year ago have not started treatments is it available in san jose ca?

    • There new study is with ribavirin, I just called. ribaviri is a toxic chemo drug, i would wait for a no interferon or ribavirn drug in the treatment mix

  • Haupiagirl808

    I was just diagnosed with Stage 4 Liver Disease from Hep C. When I read of this, it doesnt seem grim. Should I be worried? I am so confused. My Dr. Says my biopsy showed Stage 2, but because of my blood work she feels I am in Stage 4. Huh? I am going to start my interferon treatments with Riboflarin and Incivek as soon as my medical approves the costs. My question is, should I be worried or not? Confused! :/. Very confused :/ someone tell me please.

    • Mark

      Go to Delphi forums and join hepatitus central u can get all of the answers u want to ur ?s there very very great site with people in the same situation that we r in. Look forward to seeing u there

      • Haupiagirl808

        Aloha Mark! I am on Delphi forums now. Yesss, you are so correct. Very informative and as they say, they’ve walked the walk, alot of them. Im Haupia808. Im in the introduce myself forum, come follow me there too. Ty sooo much!!!

    • Your blood tests is more correct than the “gold standard” liver biopsy. A biopsy is not as accurate as they want you to believe, its a money maker for the hospital, doctors, pathologists. Use common sense, a so called “small” needle can only get to a small area of your liver. So it is a hit or miss. Your blood work does not lie

      • Haupiagirl808

        Ty for your reply. Yes, thats exactly what my Dr. said. She is more worried when she looks at my blood work. I also have Thrombocytopenia and Splenomegaly?!! Still Learning about all of these terms and what they entail.

  • Minister

    Biopsies are much more accurate than blood tests. Don’t be worried. Many people have good results with treatments.

  • Pat

    I’m in a study as well, here in Denver, Colorado. (2nd. time) 3rd. treatment. The first time my Ins co pd. for it. It was Interferon w/Ribavirin 3x’s a wk shots, didn’t clear the virus. Then I found the study for the Peginterferon w/Ribavirin 1x a wk shot, didn’t clear the virus either. I kept going anemic on both the treatments (side affect). So I rode it out for a few yrs. (7) Saw and read a lot of promising stuff going on. Wasn’t till Oct 2012 I found an article & study right here in my back yard.Denver, Colorado at the University of Colorado. Dr Everson heads the study. He’s written a few books on HCV. This particular treament is for non-responders genotype 1-b the hardest to treat. No shots just pills, 1 per day (am) of Daclatasvir & 2 a day (1 in am 1 in pm) of Asunaprevir. I am Chronic HCV, had a viral load of 8,816.511 I took my first dose of the meds. on Oct.23 2012 by Nov 20, 2012 I was undetected & still am. I’m on it till April 2013 (24 wks) then it’s a wait & see for the next 24 wks w/out the meds. Because as we know this virus can hide & replicate itself. I am so excited & hopefull that we finally found something for us non-responders. Hopefully these studies will go world wide.

  • Pat

    I’m
    in a study as well, here in Denver, Colorado. (2nd. Time) 3rd. Treatment. The
    first time my Ins co pd. For it. It was Interferon w/Ribavirin 3x’s a wk shots,
    didn’t clear the virus. Then I found the study for the Peginterferon w/Ribavirin
    1x a wk shot, didn’t clear the virus either. I kept going anemic on both the
    treatments (side affect). So I rode it out for a few yrs. (7) Saw and read a lot
    of promising stuff going on. Wasn’t till Oct 2012 I found an article & study
    right here in my back yard.Denver, Colorado at the University of Colorado. Dr
    Everson heads the study. He’s written a few books on HCV. This particular
    treament is for non-responders genotype 1-b the hardest to treat. No shots just
    pills, 1 per day (am) of Daclatasvir & 2 a day (1 in am 1 in PM) of
    Asunaprevir. I am Chronic HCV, had a viral load of 8,816.511 I took my first
    dose of the meds. On Oct.23 2012 by Nov 20, 2012 I was undetected & still
    am. I’m on it till April 2013 (24 wks) then it’s a wait & see for the next
    24 wks w/out the meds. Because as we know this virus can hide & replicate
    itself.

  • marsl

    I really get SOOO PISED when doctors say that people quit interferon because of sever flu like symptoms ( i could deal with that) ‘the reason people quit interferon is because of side effects which include SEVERE DEPRESSION SUICIDAL thinking & fits of PARANOIA!

  • Why does this site not let the truth out. What are you afraid of? Interferion and Ribavirin are toxic chemo drugs

    Any treatments with them including Gilead’s sofosbuviar and 5885 with ribavirin is toxic and results are not that impressive and there is no proof that you will not relapse from their treatment. Tell the truth.

  • Mark

    My most pressing question for me is can the drugs being used in interferon free protocols be removed through dialysis. While interferon I can deal with Ribavirin can not be removed through dialysis, so I am stuck in a Catch-22 situation and in the mean time my liver had degraded to stage 2.