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“+1”>Modified Staging: architectural changes, fibrosis and cirrhosis*
Change	Score
No fibrosis	0
Fibrous expansion of some portal areas, with or without short fibrous septa	1
Fibrous expansion of most portal areas, with or without short fibrous septa	2
Fibrous expansion of most portal areas with occasional portal to portal (P-P) bridging	3
Fibrous expansion of portal areas with marked bridging [portal to portal (P-P) as well as portal to central (P-C)]	4
Marked bridging (P-P and/or P-C) with occasional nodules (incomplete cirrhosis)	5
Cirrhosis, probable or definite	6
References Ishak K, et al. Histological grading and staging of chronic hepatitis. J Hepatol 1995;22:696-699. Knodell RG, et al. Formulation and application of a numerical scoring system for assessing histological activity in asymptomatic chronic active hepatitis. <ahref= “https://www.hepatitiscentral.com/hepatitis-c/liver/histology/”> Hepatology1981;1(5):431-5
*Additional features which should be noted but not scored: Intra-acinar fibrosis, perivenular (‘chicken wire’ fibrosis) and phlebosclerosis of terminal hepatic venules.