Exercise and Cirrhosis | Table 2

Effects of Propranolol on the Hepatic Hemodynamic Response to Physical Exercise in Patients With Cirrhosis

table 2. Splanchnic Hemodynamics in Baseline Conditions, After Placebo or Propranolol Administration, During Exercise and 30 Minutes After Recovery Period

	Placebo or Propranolol Infusion
	Baseline	Pre-exercise	Exercise	Recovery	ANOVA

HVPG (mm Hg)
Placebo	16.9 ± 0.9	16.7 ± 0.9	19.0 ± 1.0	16.7 ± 0.8	0.04
Propranolol	19.3 ± 1.1	16.3 ± 1.0*	12.9 ± 1.1*,	16.9 ± 1.2*	0.002
HBF (mL · min1)
Placebo	1,074 ± 119	990 ± 141	810 ± 72*	843 ± 82	0.05
Propranolol	1,366 ± 123	978 ± 104*	724 ± 79*,	926 ± 91*	0.001
EHVR (dyn · s · cm5)
Placebo	1,320 ± 107	1,481 ± 172	1,895 ± 116*,	1,612 ± 125	0.03
Propranolol	1,191 ± 131	1,433 ± 151	1,623 ± 178	1,444 ± 109	ns
AzBF (mL · min1)§
Placebo	537 ± 64	522 ± 75	547 ± 70	504 ± 54	ns
Propranolol	722 ± 117	396 ± 64*	398 ± 42*	383 ± 59*	0.02

NOTE. Data are shown as means ± SEM.Abbreviations: EHVR, estimated hepatic vascular resistance; ns, not significant.* P < .05 vs. baseline. P < .05 vs. pre-exercise. Measured in 10 patients in each group. § Measured in 6 patients in each group.