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table 3

Neurovisual Impairment: A Frequent Complication of Alpha-Interferon Treatment in Chronic Viral Hepatitis

table  3.   Effect of Interferon Treatment on Neurovisual Parameters of Eyes With Baseline Normal or Abnormal P100 Latencies of Visual Evoked Responses

Baseline P100 Latency


P Value
Normal*(45 patients, 74 eyes) Abnormaldagger (24 patients, 32 eyes)

A. Before treatment
  P100 latency (ms) 117.1 ± 5.7§§ 136.0 ± 8.1# <.0001
  P100 amplitude (µV) 7.07 ± 0.80# 6.85 ± 0.80# NS
  Electroretinogram (µV) 53.1 ± 5.2# 51.8 ± 7.2# NS
  Visual acuity§ 9.1 ± 1.6## 7.9 ± 2.4# .0035
  Visual sensitivity (db) 25.1 ± 1.0** 24.2 ± 1.5*** .0120
B. End of treatment
  P100 latency (ms) 122.3 ± 10.5§§ 136.2 ± 12.8# <.0001
  P100 amplitude (µV) 8.09 ± 8.22# 6.51 ± 1.30# NS
  Electroretinogram (µV) 53.7 ± 5.4# 52.8 ± 7.5# NS
  Visual acuity,§ 8.9 ± 1.8## 7.5 ± 2.4 .0021
  Visual sensitivity (db) 24.1 ± 1.7** 22.3 ± 3.5*** .0201

Abbreviation: NS, not significant.
* VER <127 ms.
dagger VER 127 ms.
Mean ± SD.
§ Snellen score (in 10ths).
§§ P = .0002 (paired and group comparisons).
#P = NS.
##P = .021 (paired and group comparisons).
** P < .001 (paired and group comparisons).
P = .051 (paired comparisons).
*** P = .032 (paired comparisons).

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