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table 4

Neurovisual Impairment: A Frequent Complication of Alpha-Interferon Treatment in Chronic Viral Hepatitis

table  4.   P100 Latency and Central Visual Sensitivity at Baseline and at the End of Interferon Treatment of Eyes With Normal Pretreatment Visual and Neurophysiological Parameters

Age (yrs) Visual Evoked Responses (msec)


Central Visual Sensitivity (db)


Baseline End-of-Rx Baseline End-of-Rx

Eyes with normal end-of-treatment P100 latency (n = 59)
47.5 ± 15.3*
117.0 ± 5.3
117.7 ± 5.2Dagger ,dagger
                                 

25.4 ± 0.9§,
24.5 ± 1.6#,

Eyes with abnormal end-of-treatment P100 latency (n = 15)
59.1 ± 11.0*
117.5 ± 7.1dagger ,Dagger
138.8 ± 8.7Dagger
24.4 ± 0.7Dagger ,**
23.0 ± 1.2#,**

NOTE. Group and paired comparisons are indicated by symbols representing respective P values.
Abbreviation:
NS, not significant.
* P = .007 (group comparison).
dagger P = NS.
Dagger P < .0001.
§ P = .008.

#P = .002. ** P = .016.

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