Hepatitis C, Kinetic Data of HCV and ALT and ASTTurnover in Patients With Chronic Hepatitis C | Hepatitis Central

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Hepatitis C Virus Dynamics In Vivo: Effect of Ribavirin and Interferon Alfa on Viral Turnover

table  2.   Kinetic Data of HCV and ALT and AST Turnover in Patients With Chronic Hepatitis C Responding to Treatment With rIFN- Alone or in Combination With Ribavirin (14 mg/kg of body weight)

Kinetic Parameter 3 × 3 MU rIFN–= SRC=”b_alpha.gif”> (N = 10) 3 × 6 MU rIFN–= SRC=”b_alpha.gif”> (N = 10) 3 × 6 MU rIFN–= SRC=”b_alpha.gif”> + ribavirin (N = 10)

HCV RNA

B0RNA (106/mL)

7.19 ± 14.01 7.13 ± 6.76 9.49 ± 10.99

 

 t1/2 (ln 2/k1) (d)

2.28 ± 1.17 2.54 ± 2.10 1.99 ± 1.70

 

 t1/2 (ln 2/k2) (d)

0.67 ± 0.36 0.23 ± 0.15 0.18 ± 0.19

ALT

B0ALT (U/L)

83.1 ± 56.1 84.0 ± 49.7 58.7 ± 28.8

BALT (U/L)

8.9 ± 2.5 14.6 ± 7.1 9.7 ± 3.4

 t1/2 (ln 2/k3) (d)

4.3 ± 4.4 3.2 ± 2.5 7.8 ± 9.4

  t1/2 (ln 2/k4) (d)

3.5 ± 1.5 3.7 ± 2.1 4.3 ± 3.4

AST

  B0AST (U/L)

31.3 ± 15.5 37.9 ± 17.9 29.1 ± 10.4

 

  BAST (U/L)

8.8 ± 1.8 12.3 ± 4.6 10.5 ± 2.4

 

 t1/2 (ln 2/k3) (d)

4.1 ± 5.0 2.7 ± 3.0 5.2 ± 5.9

 

 t1/2 (ln 2/k4) (d)

3.4 ± 2.0 3.4 ± 1.8 3.3 ± 3.4

 

 

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