The latest research & treatment news about Hepatitis C infection, diagnosis, symptoms and treatment.

Harvoni® (ledipasvir and sofosbuvir) and Hepatitis C

When is Harvoni® contraindicated?

You should not take Harvoni® if you also take other medicines that contain sofosbuvir. The following chart provides information regarding potentially significant drug interactions with Harvoni® (the table is not all-inclusive). Alteration in dose or regimen may be recommended based on drug interaction studies or predicted interactions. (For more information regarding the effect of co-administration of these medications with Harvoni® and recommendations for alterations in dose or regimen please visit www.Gilead.com.)

 

Drug Class Specific Drugs Within Class Contraindicated with Harvoni®
Acid Reducing Agents Antacids (e.g. aluminum and magnesium hydroxide)
H2-receptor antagonists (e.g. famotidine)
Proton-pump inhibitors (e.g. omeprazole)
Antiarrhythmics Amiodarone
Digoxin
Anticonvulsants Carbamazepine
Phenytoin
Phenobarbital
Oxcarbazepine
Antimycobacterials Rifabutin
Rifampin
Rifapentine
HIV Antiretrovirals Efavirenz
Emtricitabine
Tenofovir disoproxil
Fumarate (DF)
Regimens containing tenofovir DF and an HIV protease inhibitor/ritonavir
Elvitegravir
Cobicistat
Emtricitabine
Tenofovir DF
Tipranavir/ritonavir
HCV Products Simeprevir
Herbal Supplements St. Johns’ wort (Hypericum perforatum)
HMG-CoA Reductase Inhibitors Rosuvastatin

 

While the following drugs were evaluated in clinical trials, when used individually with Harvoni® they had no clinically significant interactions:

  • abacavir
  • atazanavir/ritonavir
  • cyclosporine
  • darunavir/ritonavir
  • efavirenz
  • emtricitabine
  • lamivudine
  • methadone
  • oral contraceptives
  • pravastatin
  • raltegravir
  • rilpivirine
  • tacrolimus
  • tenofovir disoproxil fumarate
  • verapamil

Last Updated: May 2015
 

"FDA Drug Safety Communication: FDA Warns of Serious Slowing of the Heart Rate When Antiarrhythmic Drug Amiodarone is Used with Hepatitis C Treatments Containing Sofosbuvir (Harvoni) or Sovaldi in Combination with Another Direct Acting Antiviral Drug." U.S. Food and Drug Administration, http://www.fda.gov/Drugs/DrugSafety/ucm439484.htm. Retrieved April 10, 2015.

"Full Prescribing Information." Gilead.com. Gilead Sciences, Inc., http://www.gilead.com/~/media/Files/pdfs/medicines/liver-disease/harvoni/harvoni_pi.pdf. Retrieved April 10, 2015.

"Harvoni® Coupon and Savings." Gilead.com. Gilead Sciences, Inc., https://www.harvoni.com/co-pay-coupon-registration. Retrieved April 13, 2015.

"Patient Information: Harvoni®." Gilead.com. Gilead Sciences, Inc., http://www.gilead.com/~/media/Files/pdfs/medicines/liver-disease/harvoni/harvoni_patient_pi.pdf. Retrieved April 13, 2015.

"Support Path Harvoni® and Sovaldi® Tablets Treatment Support." Gilead.com. Gilead Sciences, Inc., https://www.harvoni.com/co-pay-coupon-registration. Retrieved April 13, 2015.