Harvoni® (ledipasvir and sofosbuvir) and Hepatitis C
When is Harvoni® contraindicated?
You should not take Harvoni® if you also take other medicines that contain sofosbuvir. The following chart provides information regarding potentially significant drug interactions with Harvoni® (the table is not all-inclusive). Alteration in dose or regimen may be recommended based on drug interaction studies or predicted interactions. (For more information regarding the effect of co-administration of these medications with Harvoni® and recommendations for alterations in dose or regimen please visit www.Gilead.com.)
|Drug Class||Specific Drugs Within Class Contraindicated with Harvoni®|
|Acid Reducing Agents||Antacids (e.g. aluminum and magnesium hydroxide)
H2-receptor antagonists (e.g. famotidine)
Proton-pump inhibitors (e.g. omeprazole)
Regimens containing tenofovir DF and an HIV protease inhibitor/ritonavir
|Herbal Supplements||St. Johns’ wort (Hypericum perforatum)|
|HMG-CoA Reductase Inhibitors||Rosuvastatin|
While the following drugs were evaluated in clinical trials, when used individually with Harvoni® they had no clinically significant interactions:
- oral contraceptives
- tenofovir disoproxil fumarate
Last Updated: May 2015
"FDA Drug Safety Communication: FDA Warns of Serious Slowing of the Heart Rate When Antiarrhythmic Drug Amiodarone is Used with Hepatitis C Treatments Containing Sofosbuvir (Harvoni) or Sovaldi in Combination with Another Direct Acting Antiviral Drug." U.S. Food and Drug Administration, http://www.fda.gov/Drugs/DrugSafety/ucm439484.htm. Retrieved April 10, 2015.
"Full Prescribing Information." Gilead.com. Gilead Sciences, Inc., http://www.gilead.com/~/media/Files/pdfs/medicines/liver-disease/harvoni/harvoni_pi.pdf. Retrieved April 10, 2015.
"Harvoni® Coupon and Savings." Gilead.com. Gilead Sciences, Inc., https://www.harvoni.com/co-pay-coupon-registration. Retrieved April 13, 2015.
"Patient Information: Harvoni®." Gilead.com. Gilead Sciences, Inc., http://www.gilead.com/~/media/Files/pdfs/medicines/liver-disease/harvoni/harvoni_patient_pi.pdf. Retrieved April 13, 2015.
"Support Path Harvoni® and Sovaldi® Tablets Treatment Support." Gilead.com. Gilead Sciences, Inc., https://www.harvoni.com/co-pay-coupon-registration. Retrieved April 13, 2015.