When is Harvoni® contraindicated? | Hepatitis Central

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Harvoni® (ledipasvir and sofosbuvir) and Hepatitis C

When is Harvoni® contraindicated?

You should not take Harvoni® if you also take other medicines that contain sofosbuvir. The following chart provides information regarding potentially significant drug interactions with Harvoni® (the table is not all-inclusive). Alteration in dose or regimen may be recommended based on drug interaction studies or predicted interactions. (For more information regarding the effect of co-administration of these medications with Harvoni® and recommendations for alterations in dose or regimen please visit www.Gilead.com.)


Drug Class Specific Drugs Within Class Contraindicated with Harvoni®
Acid Reducing Agents Antacids (e.g. aluminum and magnesium hydroxide)
H2-receptor antagonists (e.g. famotidine)
Proton-pump inhibitors (e.g. omeprazole)
Antiarrhythmics Amiodarone
Anticonvulsants Carbamazepine
Antimycobacterials Rifabutin
HIV Antiretrovirals Efavirenz
Tenofovir disoproxil
Fumarate (DF)
Regimens containing tenofovir DF and an HIV protease inhibitor/ritonavir
Tenofovir DF
HCV Products Simeprevir
Herbal Supplements St. Johns’ wort (Hypericum perforatum)
HMG-CoA Reductase Inhibitors Rosuvastatin


While the following drugs were evaluated in clinical trials, when used individually with Harvoni® they had no clinically significant interactions:

  • abacavir
  • atazanavir/ritonavir
  • cyclosporine
  • darunavir/ritonavir
  • efavirenz
  • emtricitabine
  • lamivudine
  • methadone
  • oral contraceptives
  • pravastatin
  • raltegravir
  • rilpivirine
  • tacrolimus
  • tenofovir disoproxil fumarate
  • verapamil

Last Updated: May 2015

"FDA Drug Safety Communication: FDA Warns of Serious Slowing of the Heart Rate When Antiarrhythmic Drug Amiodarone is Used with Hepatitis C Treatments Containing Sofosbuvir (Harvoni) or Sovaldi in Combination with Another Direct Acting Antiviral Drug." U.S. Food and Drug Administration, http://www.fda.gov/Drugs/DrugSafety/ucm439484.htm. Retrieved April 10, 2015.

"Full Prescribing Information." Gilead.com. Gilead Sciences, Inc., http://www.gilead.com/~/media/Files/pdfs/medicines/liver-disease/harvoni/harvoni_pi.pdf. Retrieved April 10, 2015.

"Harvoni® Coupon and Savings." Gilead.com. Gilead Sciences, Inc., https://www.harvoni.com/co-pay-coupon-registration. Retrieved April 13, 2015.

"Patient Information: Harvoni®." Gilead.com. Gilead Sciences, Inc., http://www.gilead.com/~/media/Files/pdfs/medicines/liver-disease/harvoni/harvoni_patient_pi.pdf. Retrieved April 13, 2015.

"Support Path Harvoni® and Sovaldi® Tablets Treatment Support." Gilead.com. Gilead Sciences, Inc., https://www.harvoni.com/co-pay-coupon-registration. Retrieved April 13, 2015.