The latest research & treatment news about Hepatitis C infection, diagnosis, symptoms and treatment.


Do the Enzymes Found in Papaya Help Hepatitis C?

Back to News Homepage


Hepatitis C Drug Labeling Update

Simeprevir and VX-135 Team Up in Phase II Hep C Trial

November 7, 2012

Print this page

Vertex’s VX-135 is being paired with Medivir and Janssen’s simeprevir in an all-oral Phase II Hepatitis C trial.

Phase II All-oral Study Of Simeprevir And VX-135 For The Treatment Of Hepatitis C

By News Staff | November 3rd 2012

Medivir AB has announced plans for a phase II proof-of-concept study of an all-oral regimen for the treatment of hepatitis C containing of Medivir/Janssen’s protease inhibitor simeprevir and Vertex’s nucleotide analogue hepatitis C virus (HCV) polymerase inhibitor VX-135. Janssen will conduct a drug-drug interaction study with simeprevir and VX-135 to support the planned initiation of a phase II proof-of-concept study in early 2013, pending discussions with regulatory authorities.

The phase II study is expected to evaluate safety, tolerability and viral cure rates using a 12-week combination of simeprevir and VX-135, with and without ribavirin. Janssen and Vertex will jointly fund development costs associated with the collaboration. There are no up-front or milestone payments associated with the agreement.

Continue reading this entire article:

Requirements for using and reposting articles

  • Christina

    I have had hep c geno type 1a for at least 35 years. I have waited for years and years for the industry to create a cure for this. It looks like we are very close. In the meantime and even if one takes a treatment, liver damage is a big concern so either way repair to the liver is critical. The great thing is the liver has amazing regenerative powers especially with some help. After years of searching I have finally found something that has saved my life. I was so sick I could barely function and my ferritan/iron levels plus liver function tests were really high. I had no hormone levels and pretty wiped out with not much of a life. I have found a medical food ( nutraceutical) that is prescribed by practitioners that I will say again has saved my life. The founder of this company was on a liver transplant list and the result of perseverance and determination plus top connections in the scientific/medical community he teamed up and created this formulation. The formulations got him off the transplant list and back living a healthy extremely active life. This has blessed my life and I know there are so many like myself this will benefit so I am posting. My goal is to eradicate the virus when these fantastic new treatments become available however, I now know with this medical food and then the new treatments its more than a win win- it’s restoring life back to they way we are intended to be! Feel free to email me if you would like more information.