Cryptogenic Cirrhosis: Clinical Characterization and Risk Factors for Underlying Disease
| table 1. Demographic, Clinical, and Laboratory Parameters of 70 Patients With Cryptogenic Cirrhosis |
|
| Parameter |
Total
Cryptogenic
Cirrhosis |
Prior Blood
Transfusion
(+/ NASH
Risks) |
IAH Score
 10 With No
Prior Blood Tx
(+/ NASH
Risks) |
NASH Risks
Only (IAH
Score <10 and
No Prior
Blood Tx) |
No Risk
Identified |
|
| N |
70 |
19 |
19 |
25 |
7 |
| Age (yr) |
63 ± 11 |
61 ± 11 |
65 ± 10 |
62 ± 11 |
68 ± 12 |
| Female |
49 (70%) |
16 (84%) |
17 (89%) |
12 (48%) |
4 (57%) |
| DM or obesity* |
51 (73%) |
14 (74%) |
12 (63%) |
25 (100%) |
0 (0%) |
| Diabetes mellitus |
37 (53%) |
8 (42%) |
10 (53%) |
19 (76%) |
0 (0%) |
| Marked obesity* |
33 (47%) |
11 (58%) |
8 (42%) |
14 (56%) |
0 (0%) |
| Prior blood Tx |
19 (27%) |
19 (100%) |
0 |
0 |
0 |
| IAH score |
8 ± 2 |
7 ± 3 |
11 ± 1 |
7 ± 2 |
8 ± 1 |
| Solvent exposure |
5 |
1 |
1 |
2 |
1 |
| Family Hx liver disease |
13 (19%) |
1 (5%) |
5 (25%) |
6 (24%) |
1 (14%) |
| Family history autoimmune disease |
15 (21%) |
4 (21%) |
2 (11%) |
8 (32%) |
1 (14%) |
| AST (7-40 IU/L) |
60 ± 54 |
63 ± 86 |
67 ± 49 |
51 ± 26 |
61 ± 30 |
| ALT (6-65 IU/L) |
46 ± 37 |
44 ± 41 |
52 ± 47 |
41 ± 26 |
48 ± 27 |
| AST/ALT ratio |
1.5 ± 0.9 |
1.3 ± 0.4 |
1.8 ± 1.2 |
1.5 ± 0.9 |
1.7 ± 0.8 |
| AP (38-126 IU/L) |
148 ± 71 |
154 ± 85 |
141 ± 69 |
163 ± 79 |
134 ± 52 |
| ANA (1:40) |
31 (44%) |
6 (32%) |
16 (80%) |
8 (32%) |
1 (14%) |
IgG (694-1618 mg/dL) |
1,719 ± 704 |
1,737 ± 635 |
1,846 ± 807 |
1,661 ± 614 |
1,230 ± 318 |
| IgA (68-378 mg/dL) |
588 ± 405 |
617 ± 397 |
559 ± 426 |
590 ± 385 |
325 ± 161 |
| IgG/IgA ratio |
3.6 ± 1.7 |
3.5 ± 1.9 |
3.9 ± 1.6 |
2.9 ± 1.5 |
4.2 ± 1.4 |
A1A PI type : MZ, MS, MF, SS |
14/42 (33%) |
2/10 (20%) |
6/15 (40%) |
4/14 (29%) |
2/3 (67%) |
| Abnormal Fe indices§ |
11 (16%) |
1 (5%) |
3 (16%) |
6 (24%) |
1 (14%) |
| Prior abnormal liver enzymes (known) |
20 (29%) |
5 (26%) |
5 (26%) |
10 (32%) |
0 (0%) |
Liver-related death |
9 (13%) |
2 (11%) |
3 (16%) |
4 (16%) |
0 (0%) |
| Hepatoma |
1 (1.4%) |
1 (5.2%) |
0 (0%) |
0 (0%) |
0 (0%) |
|
NOTE. The first column shows data from all of the patients. The remaining four columns show comparison data between the patients after dividing into four major risk groups. DM reflects Type 2 diabetes mellitus.
* Marked obesity was defined as BMI >31.1 male, BMI >32.3 female (95th percentiles).
Quantitative immunoglobulins were performed in 52 patients.
 1-Antitrypsin phenotyping was performed in 42 patients.
§ Eleven patients had abnormal iron indices (either elevated ferritin or iron saturation), but none had histological evidence of hemochromatosis.
Liver-related deaths refer to deaths during the approximately 3-year data-collection period that were known to be related to cirrhosis. |
|
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