DNA of Hepatitis C Virus Genome

Full-Length Complementary DNA of Hepatitis C Virus Genome From an Infectious Blood Sample

table 1. Sequences of HVR and Number of Clones Recovered

Clone	Sequence of HVR	No. of Clones^*
		Donor	Chimp 3 Wk	Recipient
		Donor	Chimp 3 Wk	4 Wk	5 Wk	14 Wk	16 Wk

	384410^§
A1	HYRVTRGVQGHVTSTLTSLFRPGASQK	18	1	2	1	0	0
A2	S————————–	3	0	0	0	0	0
B1	N-H—A—-GAFG—–Q——	5	19	0	0	2	0
B2	D-H—A—-GAFG—–Q——	0	0	0	1	1	0
B3	D-H—A—-GAF——TL—–	1	0	0	0	0	0
B4	N-H—A—-GAF——TS—–	0	0	1	0	0	0
B5	D-H—A—-GAF——TS—–	2	0	0	0	1	0
B6	D-H—A—-GAFQ—–TS—–	0	0	1	0	0	0
B7	D-H—A—-GAFQ—–TS—-R	0	0	1	0	0	0
B8	D-H—A—-GAFH—–TS—–	0	0	2	8	6	0
B9	D-H—A–C-GAFH—–TS—–	0	0	1	0	0	0
C1	–H—A—RSV-K–AF-T–P—	1	0	0	0	0	0
C2	N-H——-R-A-K—F-T–P—	0	0	1	0	0	0
D1	–H—————FK-S—–	0	0	1	0	0	0
E1	E-H—-SA–TV-GFV–LA—K-N	0	0	0	0	0	10
Total		30	20	10	10	10	10

^* Numbers of clones recovered from plasma of donor, chimpanzee, and recipient are shown here; wk, weeks posttransfusion. Clone names shown in Fig. 4. Number according to Hijikata et al.³⁸ ^§ Numbers written above amino acid residues indicate positions in polyprotein of HCV. Dashes represent amino acid residues identical to the A1 clone.