Hepatitis C, High Prevalence of the His63Asp HFEMutation in Italian Patients With Porphyria Cutanea Tarda

High Prevalence of the His63Asp HFE Mutation in Italian Patients With Porphyria Cutanea Tarda

table 2. Allelic and Genotype Frequencies of Two Mutations of HFE in 68 Patients With PCT Sorted According to Their Iron Status

	Class 0 (n = 16)	Class I (n = 39)	Class II (n = 13)	P

Alleles
Cys282Tyr	0/32	1/78 (3.3%)	1/26 (3.8%)	NS
His63Asp	12/32 (37.5%)	23/78 (29.5%)	6/26 (23.1%)	NS
Genotypes
Cys282/Tyr282	0/16	1/39 (2.6%)	1/13 (7.7%)	NS
Tyr282/Tyr282	0/16	0/39	0/13	NS
His63/Asp63	6/16 (37.5%)	17/39 (43.6%)	6/13 (46.1%)	NS
Asp63/Asp63	3/16 (18.7%)	3/39 (7.7%)	0/13	NS

NOTE. Iron class status as follows: class 0, normal iron status; class I, mild to moderate iron overload; and class II, severe iron overload. Abbreviation: NS, not significant.