| table 2. Observed and Expected Numbers and SIR of Cancer in 11,605 Patients With Cirrhosis |
|
| Cancer Site |
Both Sexes
|
Men
|
Women
|
| Observed |
Expected |
SIR |
95% CI |
Observed |
SIR |
Observed |
SIR |
|
| All malignant neoplasms |
1,447 |
708.1 |
2.0 |
1.9-2.2 |
896 |
2.2* |
551 |
1.8* |
| Liver (primary) |
245 |
6.8 |
36.0 |
31.6-40.8 |
182 |
40.2* |
63 |
27.8* |
| Hepatocellular carcinoma |
199 |
3.3 |
59.9 |
51.8-68.8 |
152 |
59.5* |
47 |
97.8* |
| Cholangiocarcinoma |
21 |
2.1 |
10.0 |
6.2-15.2 |
13 |
11.4* |
8 |
8.3* |
| Other and unspecified morphologies |
25 |
1.4 |
18.3 |
11.8-27.0 |
17 |
20.6* |
8 |
14.8* |
| Tobacco-related sites, total |
356 |
188.6 |
1.9 |
1.7-2.1 |
244 |
1.8* |
112 |
2.2* |
| Lung |
207 |
102.5 |
2.0 |
1.8-2.3 |
143 |
1.9* |
64 |
2.5* |
| Urinary bladder |
62 |
45.8 |
1.4 |
1.0-1.7 |
47 |
1.3 |
15 |
1.7 |
| Kidney |
45 |
20.1 |
2.2 |
1.6-3.0 |
27 |
2.1* |
18 |
2.5* |
| Pancreas |
42 |
20.1 |
2.1 |
1.5-2.8 |
27 |
2.4* |
15 |
1.7 |
Alcohol-related sites, total |
241 |
31.3 |
7.7 |
6.8-8.7 |
173 |
7.0* |
68 |
10.5* |
| Buccal cavity and pharynx |
143 |
15.5 |
9.2 |
7.8-10.8 |
96 |
8.1* |
47 |
12.9* |
| Esophagus |
54 |
7.2 |
7.5 |
5.6-9.8 |
41 |
7.4* |
13 |
7.7* |
| Larynx |
44 |
8.5 |
5.2 |
3.8-6.9 |
36 |
4.9* |
8 |
7.1* |
| Hormone-related sites, total |
151 |
135.4 |
1.1 |
0.9-1.3 |
42 |
1.0 |
109 |
1.2* |
| Breast |
83 |
63.7 |
1.3 |
1.0-1.6 |
2 |
3.2 |
81 |
1.3* |
| Endometrium |
14 |
16.5 |
0.9 |
0.5-1.4 |
 |
|
14 |
0.9 |
| Ovary |
14 |
13.7 |
1.0 |
0.6-1.7 |
|
|
14 |
1.0 |
| Prostate |
40 |
41.6 |
1.0 |
0.7-1.3 |
40 |
1.0 |
|
|
| Other sites, total |
454 |
346.0 |
1.3 |
1.2-1.4 |
255 |
2.0* |
199 |
1.3* |
| Stomach |
40 |
21.3 |
1.9 |
1.3-2.6 |
28 |
2.0* |
12 |
1.7 |
| Colon |
82 |
55.4 |
1.5 |
1.2-1.8 |
42 |
1.5* |
40 |
1.5* |
| Rectum |
40 |
32.4 |
1.2 |
0.9-1.7 |
23 |
1.1 |
17 |
1.5 |
| Gallbladder and biliary tract |
8 |
6.0 |
1.3 |
0.6-2.6 |
3 |
1.3 |
5 |
1.4 |
| Cervix uteri |
11 |
10.4 |
1.1 |
0.5-1.9 |
|
|
11 |
1.1 |
| Testis |
8 |
3.5 |
2.3 |
1.0-4.5 |
8 |
2.3 |
|
|
| Melanoma |
8 |
15.2 |
0.5 |
0.2-1.0 |
2 |
0.3* |
6 |
0.8 |
| Nonmelanoma skin |
120 |
100.0 |
1.2 |
1.0-1.4 |
62 |
1.0 |
58 |
1.4* |
| Brain and nervous system |
9 |
17.2 |
0.5 |
0.2-1.0 |
5 |
0.5 |
4 |
0.6 |
| Thyroid |
4 |
2.2 |
1.8 |
0.5-4.6 |
3 |
3.4 |
1 |
0.7 |
| Non-Hodgkin’s lymphoma |
19 |
14.9 |
1.3 |
0.8-2.0 |
12 |
1.4 |
7 |
1.2 |
| Leukemia |
20 |
15.8 |
1.3 |
0.8-2.0 |
13 |
1.3 |
7 |
1.3 |
|
NOTE. First years of follow-up excluded.
* P < .05. Liver not included; sites also influenced by tobacco.
 Not all sites shown. |
