7 Ways Hepatitis C Affects Women Differently than Men | Hepatitis Central

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7 Ways Hepatitis C Affects Women Differently than Men

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Although the virus itself does not discriminate against gender, these seven differences between men and women with Hepatitis C are worth reviewing.
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First discovered as a contagious virus in 1989, Hepatitis C currently infects an estimated four million Americans. While this highly transmissible virus does not discriminate against sexuality, age or race, there are some factors contributing to Hepatitis C’s slightly different impact on men and women.

More people die annually with Hepatitis C than HIV, the virus that causes AIDS; but Hepatitis C education pales in comparison. Increased public health efforts have steadily improved Hepatitis C awareness, but most experts agree we still have a far way to go.

Learning about some of the different issues attributed to Hepatitis C and gender does not change the fact that Hepatitis C is a highly contagious, blood-borne virus. If infected blood makes contact with the blood of someone who is not infected, both men and women are susceptible to chronic Hepatitis C infection – regardless of their gender. However, variations between how the virus impacts the sexes could lend some insight to future treatment, prevention and research efforts.

Seven ways Hepatitis C affects women and men differently are described below:

  1. Developing Cirrhosis – According to the U.S. Centers for Disease Control and Prevention, scarring of the liver (cirrhosis) occurs in 5 to 20 percent of people with chronic Hepatitis C. However, women seem to be more protected against liver cirrhosis than men. According to a 20 year multi-center German study published in the journal Hepatology in July 2000, only .004 percent of the 1,018 women studied developed cirrhosis. Experts believe that the female hormone estrogen protects women from liver damage – making them less susceptible to cirrhosis. If this is the case, the protective effect may diminish after menopause, when women’s bodies produce less estrogen.
  2. Intravenous Drug Use with a Sexual Partner – Although there are many ways of being exposed to a blood-borne virus, sharing intravenous drug needles is the easiest way to transmit Hepatitis C. According to a study published nearly ten years ago in the journal Emerging Infectious Diseases, researchers found that women are more likely to share needles or start using intravenous drugs with a sexual partner than men are.
  3. Spontaneous Clearance – Of those infected, about 85 percent will develop chronic Hepatitis C infection. The other 15 percent are lucky; their bodies are able to get rid of the virus without medication. This phenomenon is known as spontaneous clearance. However, spontaneous clearance seems weighted toward women. Based on a 2014 study published in the journal Hepatology, women are more likely than men to have spontaneous clearance. Researchers do not know why the Hepatitis C clearance rate is higher in women than men but suspect that estrogen’s liver protective property may be partly responsible.
  4. Menstruation Transmission – Sexual transmission of Hepatitis C is uncommon, with most studies showing that 0 to 3 percent of people in a steady, monogamous relationship with a Hepatitis C-positive partner become infected through unprotected heterosexual intercourse. Similar to HIV, Hepatitis C may be more efficiently transmitted through anal sex than through vaginal intercourse because of the greater risk of blood exposure. However, Hepatitis C is more likely to be sexually transmitted when a woman is having her menstrual period (from the menstruating woman to her partner) due to the presence of blood.
  5. Cesareans Over 22 Years Ago – Because it can be asymptomatic for 20 to 30 years or more, many people remain unaware that they have Hepatitis C. Before 1992 when testing for Hepatitis C began, this virus was often contracted via blood transfusions. In the 1970s and 1980s, before Hepatitis C was identified, women often received blood transfusions when they underwent Cesarean delivery (C-section) – and some were unaware that they received donated blood. Thus, experts suggest that women who had a C-section before 1992 be tested for Hepatitis C.
  6. Ribavirin and Anemia – Although many new Hepatitis C drugs are in the development pipeline, all medications create side effects. One medication frequently used in combination with others to treat Hepatitis C is ribavirin. Anemia (low red blood cell count) is a serious and common side effect of ribavirin. Because women lose blood each month through menstruation, they are more likely than men to develop anemia; thus, menstruating women on ribavirin should have their blood cell levels monitored regularly.
  7. Hormone Pills – Oral contraception pills are the most popular contraceptive method in the U.S. and are generally safe for women with Hepatitis C. Likewise, hormone replacement therapy (HRT) is one of the most common routes for supporting menopausal women and it is generally safe for women with Hepatitis C. Unfortunately, estrogen-containing pills (oral contraception and HRT) are not advisable for women with severe liver disease. Because a significantly damaged liver may not be able to break down these hormones, those with severe liver disease should consult their doctor (and maybe even get a second opinion) if considering oral contraception or HRT.

With an estimated four million Americans living with chronic Hepatitis C, improved public education efforts are in demand. Although blood-to-blood contact poses a Hepatitis C infection risk to anyone, the seven circumstances listed above demonstrate slight differences in how the Hepatitis C virus impacts woman and men.


http://health.usnews.com/health-news/news/articles/2012/02/20/hepatitis-c-now-kills-more-americans-than-hiv, Hepatitis C Now Kills More Americans than HIV, Steven Reinberg, Retrieved June 1, 2014, US News & World Report, 2014.

http://onlinelibrary.wiley.com/doi/10.1002/hep.26639/abstract;jsessionid=12E1A42F80035F0CFC1A3DF853CF9FDD.f04t02, The effects of female sex, viral genotype, and IL28B genotype on spontaneous clearance of acute hepatitis C virus infection, Jason Grebely, et al, Retrieved May 30, 2014, Hepatology, January 2014.

http://www.cdc.gov/hepatitis/hcv/hcvfaq.htm, Hepatitis C FAQs for Health Professionals, Retrieved June 1, 2014, US Centers for Disease Control and Prevention, 2014.

http://www.guttmacher.org/pubs/fb_contr_use.html, Contraceptive Use in the United States, Retrieved June 1, 2014, Guttmacher Institute, 2014.

http://www.hcvadvocate.org/hepatitis/hepc/wmnlong.html, Women and HCV, Liz Highleyman, Retrieved May 26, 2014, Hepatitis C Support Project, 2014.

http://www.healthline.com/health-slideshow/hepatitis-c-symptoms-women, What Are the Symptoms of Hepatitis C in Women?, Diana Bocco, Retrieved May 29, 2014, Healthline Networks, Inc., 2014.

http://www.hepatitisaustralia.com/women-and-hep-c/, Women and Hepatitis C, Retrieved May 30, 2014, Hepatitis Australia, Inc., 2014.

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3329031/, Prevention of Hepatitis C in Women, Beth P. Bell, et al, Retrieved June 1, 2014, Emerging Infectious Diseases, November 2004.

http://www.ncbi.nlm.nih.gov/pubmed/10869294, Low Frequency of Cirrhosis in a Hepatitis C (genotype 1b) single-source outbreak in Germany – a 20-year multicenter study, Wiese M, et al, Retrieved June 1, 2014, Hepatology, July 2000.

http://www.ncbi.nlm.nih.gov/pubmed/23908124, The effects of female sex, viral genotype, and IL28B genotype on spontaneous clearance of acute hepatitis C virus infection, Grebely J, et al, Retrieved June 1, 2014, Hepatology, January 2014.

http://www.sciencedaily.com/releases/2013/09/130912112812.htm, Women Have Higher Rates of Spontaneous Clearance of Hepatitis C Virus, Retrieved May 30, 2014, ScienceDaily, LLC, 2014.


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