Advancement Made on Thwarting Hep C Replication and Resistance
UCLA researchers identify peptide that inhibits replication of hepatitis C virus
By Kim Irwin February 02, 2012
Researchers from UCLA’s Jonsson Comprehensive Cancer Center have identified a cell-permeable peptide that inhibits a hepatitis C virus protein and blocks the viral replication that can lead to liver cancer and cirrhosis.
The finding by Dr. Samuel French, a UCLA assistant professor of pathology and senior author of the research, builds on previous work by French’s laboratory that identified two cellular proteins that are important factors in hepatitis C virus infection.
In that earlier research, French and his team set out to identify the cellular factors involved in hepatitis C replication. Using mass spectrometry, they found that heat-shock proteins (HSPs) 40 and 70 were important for viral infection. HSP 70 was previously known to be involved, but the study linked HSP 40 for the first time to hepatitis C infection. The researchers further showed that the natural compound quercetin, which inhibits the synthesis of these proteins, significantly inhibited viral infection in tissue culture.
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