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Declaration of Hepatitis C Cure is Misleading

The Editors at Hepatitis Central
May 31, 2007

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Here is an example of an article on the recent claims of a Hepatitis C “cure.” Readers should take note that the study included those who have already beaten the virus with interferon combination therapy (ICT). The good news is that once you beat the virus with ICT, you are likely to remain virus-free. The bad news is that ICT only helps approximately one quarter of those infected with the most common strain of the virus, when you take into account those who had to stop or adjust their treatment due to the severe side effects.

Drug combination found effective against hepatitis C, but there’s a catch
By Bob Lamendola

FORT LAUDERDALE, Fla. — Doctors and researchers almost never use the word “cure,” but they came as close as they ever do Monday when describing a combination of two drugs used to treat the severe liver disease hepatitis C.

Among some patients, the drug cocktail of pegylated interferon and ribavirin completely kills the virus that causes hepatitis C, and keeps it from coming back, doctors said in reporting their new study at a Digestive Disease Weekly conference in Washington, D.C.
The catch is, the drug combo does not work in about half of people with hepatitis C, and researchers still are not sure why it works so completely for some but fails in others. Also, the combo has difficult side effects.

“I call it a cure. It doesn’t work for everyone but it has the ability to eradicate this virus, and this study is the best evidence to prove that,” said Dr. Eugene Schiff, director of the center for liver diseases at the University of Miami medical school, who was attending the conference but not involved in the study.

The findings of the six-nation study, headed in the United States by Virginia Commonwealth University, solidifies the drug combination as the top treatment for the virus, which has infected about 4 million Americans.

The virus spreads only via direct contact with infected blood. Most cases stem from blood transfusions before 1992 and intravenous needle use, but the virus also can occasionally be passed through sex.

Long-term infection of hepatitis C has caused a leap in the incidence of liver cancer and liver damage, and is the leading cause of people needing liver transplants. The virus kills more people than HIV/AIDS.

The new study followed 997 patients who had cleared the virus from their systems while taking the drug combo for almost a year. Of those, 99 percent remained virus-free an average of four years after they stopped taking the drugs, and as long as seven years later.

That kind of success is not seen with other viruses, such as hepatitis B and HIV, which hide in the body and come back strong if the patient stops taking the medicine, said Dr. John Vierling, a Baylor College professor and past president of the American Association for the Study of Liver Diseases.

“This is a virus we can beat,” said Vierling, who was not associated with the study.
But the drug combo only defeats the virus in about 40 percent of those infected with the most common strain of hepatitis C, which accounts for two-thirds of cases. Blacks and those with serious cirrhosis of the liver are less likely than average to do well. The drugs succeed about 80 percent of the time against other strains of the virus.

The side effects from the drugs can be serious. Most people experience little more than flulike symptoms, but small numbers report hair loss, depression, moodiness, sharp anemia, and in rare cases, heart and kidney failure, suicidal thoughts and even death.

“People don’t like to take it if they don’t have to,” Schiff said.

Plantation, Fla., patient Andi Thomas, who founded the nationwide advocacy group Hep-C Alert, said she has been virus-free since taking the combo in 2004, with only headaches as a side effect. The group is funded in part by Roche Inc., which makes the interferon drug.

“I would like to hope I am cured forever and ever,” Thomas said. “I would like for them to have better drugs, but right now they don’t. It’s the best tool we have.”

Are you looking for further clarification on genotypes and success rates of combination therapy? Be sure to also read the article, A Cure for Hepatitis C posted on


Surviving Hepatitis C: A Personal Story

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