The latest research & treatment news about Hepatitis C infection, diagnosis, symptoms and treatment.

Previous

Schering-Plough Developing Potent Protease Inhibitor for Hepatitis C

Back to News Homepage

Next

Interferon Inappropriate for Long-Term Hepatitis C Treatment

Hep C Study Reveals Taribavirin a Good Alternative to Ribavirin

Print this page

At the end of a 48-week, Phase IIb study, taribavirin shows similar effectiveness as ribavirin in reducing Hepatitis C viral load. However, participants taking taribavirin had a significantly lower rate of anemia.

Valeant reports encouraging results from Phase IIb hepatitis study

25th November 2008
By Staff Writer

Valeant Pharmaceuticals, a multinational specialty pharmaceutical company, has reported promising results at end of treatment, week 48 analysis point in the Phase IIb clinical trial for its antiviral compound, taribavirin, a prodrug of ribavirin in development for the treatment of chronic hepatitis C in conjunction with a pegylated interferon.

Similar to the treatment week 12 results reported earlier in 2008, the 48-week viral response data continue to show comparable reductions in viral load for weight-based doses of taribavirin and ribavirin. The anemia rate was statistically significantly lower for patients receiving taribavirin in the 20mg/kg and 25mg/kg arms versus the ribavirin control arm.

The Phase IIb trial is a US multi-center, randomized, parallel, open-label study in 278 treatment-naive, genotype 1 patients evaluating taribavirin at 20 mg/kg, 25 mg/kg, and 30 mg/kg per day in combination with pegylated interferon alfa-2b. The control group is being administered weight-based dose ribavirin (800/1000/1200/1400mg daily) and pegylated interferon alfa-2b. Overall treatment duration is 48 weeks with a post-treatment follow-up period of 24 weeks.

Michael Pearson, chairman and CEO of Valeant, said: “We believe that taribavirin will be a promising alternative to ribavirin in the treatment of chronic hepatitis C and, with Valeant’s strategic shift away from the infectious disease market, we plan to out-license this compound in order to maximize its potential for these patients.”

URL for Article Source:
http://www.pharmaceutical-business-review.com/article_news.asp?guid=
02C2D191-166C-4F5C-AA9E-CAEE307BE5B6

No Comments - be the first!
Share
Share

Previous

Schering-Plough Developing Potent Protease Inhibitor for Hepatitis C

Back to News Homepage

Next

Interferon Inappropriate for Long-Term Hepatitis C Treatment

Requirements for using and reposting articles

Comments

HepatitisCentral.com provides information regarding hepatitis and liver disease. Comments are available to the community in order to discuss these topics and obtain answers to questions through community members. The Editors at HepatitisCentral.com will not be responding to questions or comments posed in article comments.