How You Can Stop HCV from Leading to Gallstones | Hepatitis Central

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How You Can Stop HCV from Leading to Gallstones

The Editors at Hepatitis Central
February 26, 2007

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Recent research has shown how Hepatitis C patients have a greater tendency to develop gallstones. Learn how to prevent your diagnosis from leading to one of the 1 million new cases of gallstones reported each year.

by Nicole Culter, L.Ac.

Gallstone disease is the most common disorder affecting the body’s biliary system, the network of organs and ducts responsible for creating, transporting, storing and releasing bile. Responsible for the digestion of fat, bile is a fluid produced by the liver and stored in the gallbladder. Bile primarily consists of water, cholesterol, fats, bile salts, proteins and bilirubin. If the chemical balance of bile contains too much of any of these components, particularly cholesterol, crystals form and harden into gallstones.

Gallstones can be as small as a grain of sand or as large as a golf ball. The gallbladder can develop just one large stone, hundreds of tiny stones, or anywhere in between. When gallstones lodge in bile ducts, they can prevent the flow of bile or digestive enzymes or lead to severe abdominal pain, vomiting, inflammation and possible infection.


Symptoms of gallstones are often called a gallstone “attack” because they occur suddenly. A typical attack can cause:

  • Steady pain in the upper abdomen that increases rapidly and lasts from 30 minutes to several hours
  • Pain in the back between the shoulder blades
  • Pain under the right shoulder
  • Nausea or vomiting

Gallstone attacks often follow fatty meals, and they may occur during the night. Other gallstone symptoms include:

  1. Abdominal bloating
  2. Recurring intolerance of fatty foods
  3. Belching
  4. Gas
  5. Indigestion

The Link Between Hepatitis C and Gallstones

Over the years, the medical community has suspected a connection between liver disease and gallbladder disease. Researchers looking to prove this suspicion have shown how people with Hepatitis C have a greater tendency to develop gallstones.

  • An Italian study published in the Archives of Internal Medicine in 1999 suggested that cirrhosis represents a major risk factor for gallstones.
  • A New York study published in the May 2005 issue of Hepatology concluded that chronic Hepatitis C infection demonstrated a strong association with gallbladder disease and that gallbladder disease was more common in adults with severe liver disease.
  • Published in the September 2005 issue of Journal of Gastroenterology and Hepatology, a Taiwanese study involving nearly 30,000 people confirmed that infection with Hepatitis C contributes to gallstone formation.

How This Impacts People with Hepatitis C

Considering the clinical proof that people with chronic Hepatitis C are at a greater risk for developing gallbladder disease, those harboring this virus are strongly encouraged to practice gallstone prevention.

Diet modification is the primary method to prevent gallstones from developing. Increasing consumption of both soluble and insoluble fiber may prevent gallstones. Fiber reduces the absorption of deoxycholic acid by producing a favorable shift in the triad of factors controlling cholesterol’s solubility in bile. Soluble fibers that are effective include guar gum and pectin, as well as oat bran, wheat bran, and soy fiber, all of which are found in many fruits and vegetables.

Additionally, regular, vigorous, exercise may decrease gallstone risk. One study, reported by WebMD, found that men who performed endurance activities for 30 minutes, five times a week, experienced a 34 percent reduction in gallbladder disease risk. The benefits derived from exercise were more dependent on intensity than type of exercise. Researchers theorize that exercise helps to normalize blood sugar and insulin levels which may contribute to gallstones when abnormal.

Evidence gathered on gallstone formation clearly points to an increased risk for individuals with the Hepatitis C virus. While people with chronic Hepatitis C likely have plenty of other health concerns, practicing gallstone prevention is easy due to its similarity to liver supportive lifestyle changes. Now there is one more reason for those with liver disease to incorporate healthful habits by increasing the fiber in their diet and getting started on a regular exercise routine.


Bini EJ, McGready J, Prevalence of gallbladder disease among persons with hepatitis C virus infection in the United States, Hepatology, May 2005.

Conte D, et al., Close relation between cirrhosis and gallstones: cross-sectional and longitudinal study, Archives of Internal Medicine, July 1999.

T S Chang, et al., Hepatitis C virus infection facilitates gallstone formation, Journal of Gastroenterology and Hepatology, September 20, 2005., Gallstones, National Digestive Diseases Information Clearinghouse, November 2004., Preventing Gallstones, Tracee Cornforth, About, Inc., 2006.

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