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Vitamin B12 During Hepatitis C Treatment

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Although requiring further investigation, a study has demonstrated Vitamin B12 as capable of boosting the success of Hepatitis C treatment.

The recent addition of a third medication to the standard Hepatitis C drug cocktail has dramatically improved the cure rate, but there are still a significant number of people who don’t respond to treatment. Especially for previous non-responders, strategies to boost the chances of a successful Hepatitis C treatment are in great demand. New research suggests that supplementing with Vitamin B12, an inexpensive, easily accessible vitamin, could be the Hepatitis C treatment accelerator that is urgently sought.

About Hepatitis C Treatment

A viral infection of the liver, Hepatitis C can go undetected for decades due to a lack of symptoms in its earlier stages. Infection that is not treated or managed can progress to advanced liver disease, which could lead to cirrhosis, liver cancer and liver failure. For the past decade, the treatment for Hepatitis C involved two drugs – interferon and ribavirin:

  • Those with the most common strain of Hepatitis C in North America, genotype 1, have a 50 percent chance of successful treatment with these medications.
  • Interferon and ribavirin are known to cause severe side effects, some of which frequently lead to discontinuation of treatment.

As of spring 2011, two new drugs joined the arsenal against Hepatitis C. Adding one of the protease inhibitor agents (boceprevir or telaprevir) to the interferon and ribavirin regimen has since boosted the Hepatitis C genotype 1 treatment success rate to about 75 percent. Although still dependent on interferon and ribavirin, the new standard of care in treating Hepatitis C infection is now a three drug protocol. Increasing the odds past 75 percent is particularly important for those who were previously unresponsive to the interferon and ribavirin duo. An Italian study has revealed that Vitamin B12 could be the way to do that.

About the Italian Study

As published in a July 2012 edition of the medical journal Gut, Italian researchers evaluated the effects of adding Vitamin B12 to interferon and ribavirin on the Hepatitis C virus. Led by Dr. Gerardo Nardone of the University of Naples, the researchers found that taking Vitamin B12 supplements may help boost the effectiveness of antiviral drugs in treating Hepatitis C.

More specifically, adding vitamin B12 to interferon and ribavirin treatment strengthened the rate of long term, sustained viral response (the current definition of a cure) by 34 percent. The increased response rate appeared to be especially prominent in participants with Hepatitis C genotype 1.

Critics of the study are basing their doubt on two points:

  • This study was relatively small, involving just 94 participants.
  • This study is not based on the current standard of care, as it only involved interferon and ribavirin (no protease inhibitor).

Even with the skepticism surrounding Nardone’s research conclusions, experts agree that further examination of Vitamin B12 on Hepatitis C treatment is warranted.

About Vitamin B12

Present only in animal food sources, Vitamin B12 is an essential water-soluble vitamin found in fish, shellfish, meat and dairy products. Also known as cobalamin, Vitamin B12 is instrumental in:

  • Keeping the body’s nerve cells healthy
  • Creating red blood cells
  • Producing DNA – the genetic material in all cells

Two steps are required for the body to absorb Vitamin B12 from food:

  1. Hydrochloric acid in the stomach separates Vitamin B12 from the protein it was originally attached to.
  2. The freed Vitamin B12 combines with a protein made by the stomach, called intrinsic factor, so that it can be absorbed by the body.

In the U.S., nutritional deficiency of this vitamin is believed to be rare – likely because the body stores several years’ worth in the liver. However, this may not be the case in people who have lived decades with a chronic liver disease like Hepatitis C.

Supplementing with Vitamin B12 is a relatively safe venture, with few reported side effects. However, Vitamin B12 may interact with several medications, such as:

  • The antibiotic chloramphenicol (Chloromycetin)
  • Proton pump inhibitors like omeprazole (Prilosec®) and lansoprazole (Prevacid®)
  • Histamine H2 receptor antagonists like cimetidine (Tagamet®), famotidine (Pepcid®) and ranitidine (Zantac®)
  • The diabetes medication Metformin

Increasing the chance of beating Hepatitis C by adding a vitamin to the treatment protocol is exciting news. Although future studies are likely to investigate this possibility further, those currently undergoing triple drug treatment for Hepatitis C may not want to wait for the final verdict. When combating a chronic illness, it is not safe to make any changes to a healthcare routine without discussing it first with a physician. As such, it seems worthwhile to discuss Vitamin B12 supplementation with the doctor guiding you through Hepatitis C triple drug therapy.

References:, Treatment of chronic hepatitis C: The new standard of care for the future, Juliana Chen, PharmD, Retrieved July 22, 2012, Formulary, August 2011., Adding Vitamin B12 to Standard Drugs Might Help Fight Hepatitis C, Retrieved July 21, 2012, US News and World Report, 2012., Vitamin B12 – Quick Facts, Retrieved July 22, 2012, National Institutes of Health, 2012., Can Vitamin B-12 Help Hepatitis-Related Fatigue?, Nicole Cutler, L.Ac., Retrieved July 22, 2012, Hepatitis Central, 2012., Vitamin B12, Retrieved July 22, 2012, Mayo Foundation for Medical Education and Research, 2012., Vitamin B12 supplementation improves rates of sustained viral response in patients chronically infected with hepatitis C virus, Rocco A, et al, Retrieved July 21, 2012, Gut, July 2012.


Hep C Trial with Sovaprevir Has 85% Success Rate

Back to News Homepage

New Study: Early Hepatitis C Progression Detection

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