When is Viekira Pak™ contraindicated? | Hepatitis Central

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Viekira Pak™ (ombitasvir, paritaprevir, and ritonavir tablets; dasabuvir tablets)

When is Viekira Pak™ contraindicated?

You should not take Viekira Pak™ if you have severe hepatic impairment (due to risk of potential toxicity).

Generally, Viekira Pak™ should not be taken with medicines that are:

  • highly dependent on CYP3A clearance.
  • strong inducers of CYP3A and CYP2C8.
  • strong inhibitors of CYP2C8.

The following chart provides information regarding drugs that are contraindicated with Viekira Pak™ (the table is not all-inclusive). (For more information regarding the effect of co-administration of these medications with Viekira Pak™ please visit www.RXAbbVie.com.)


Drug Class Specific Drugs Within Class Contraindicated with Harvoni®
Alpha1-Adrenoreceptor Antagonists Alfuzosin HCL
Anticonvulsants Carbamazepine
Antihyperlipidemic Agents Gemfibrozil
Antimycobacterials Rifampin
Ergot Derivatives Ergotamine
Ethinyl Estradiol-Containing Products Such as combined oral contraceptives
Herbal Products St. Johns’ wort (Hypericum perforatum)
HMG-CoA Reductase Inhibitors Lovastatin
Neuroleptics Pimozide
Non-Nucleoside Reverse Transcriptase Inhibitors Efavirenz
Phosphodiesterase-5 (PDE5) Inhibitors Sildenafil when dosed as Revatio for the treatment of pulmonary arterial hypertension (PAH)
Sedatives/Hypnotics Triazolam
Orally administered midazolam


For those that have a known hypersensitivity to ritonavir, Viekira Pak™ is contraindicated.

Last Updated: May 2015

Advances in Medications to Treat Hepatitis C. http://hepc.liverfoundation.org/treatment/the-basics-about-hepatitis-c-treatment/advances-in-medications/, American Liver Foundation. Retrieved May 7, 2015.

Benefits Verification. https://www.viekira.com/benefits-verification, Viekira.com. Retrieved May 7, 2015.

FDA Approves Viekira Pak to Treat Hepatitis C. http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm427530.htm, U.S. Food and Drug Administration. Retrieved May 7, 2015.

Highlights of Prescribing Information - Viekira Pak. http://www.rxabbvie.com/pdf/viekirapak_pi.pdf, AbbVie, Inc. Retrieved May 7, 2015.

proCeed Support Program. https://www.viekira.com/proceed-support, Viekira.com. Retrieved May 7, 2015.

Viekira Pak (ombitasvir/paritaprevir/ritonavir tablets; dasabuvir tablets). https://www.viekira.com/, Viekira.com. Retrieved May 7, 2015.