When is Vosevi contraindicated? | Hepatitis Central

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Vosevi (sofosbuvir, velpatasvir and voxilaprevir)

When is Vosevi contraindicated?

Vosevi is contraindicated for use with rifampin.

The following chart provides information regarding additional medications that can have potential interactions with Vosevi. This table is not all inclusive.


Drug Class Specific Drugs Within Class Contraindicated with Vosevi
Acid Reducint Agents Antacids, H2-receptor antagonists, Proton-pump inhibitors
Antiarrhythmics Amiodarone, Digoxin,
Anticoagulants Dabigatran Etexilate
Anticonvulsants Carbamazepine, Phenytoin, Phenobarbital, Oxcarbazepine
Antimycobacterials Rifampin, Rifabutin, Rifapentine
Antiretrovirals Atazanavir, Lopinavir, Tipranavir/Ritonavir, Efavirenz, Tenofovir Disoproxil Fumarate
Herbal Supplements St. Johns’ wort (Hypericum perforatum)
HMG-CoA Reductase Inhibitors Pravastatin, Rosuvastatin, Pitavastatin, Atorvastatin, Fluvastatin, Lovastatin, Simvastatin
Immunosupporessants Cyclosporine

Last Updated: October 2017

"FDA approves Vosevi for Hepatitis C" FDA.gov. U.S. Food & Drug Administration. https://www.fda.gov/newsevents/newsroom/pressannouncements/ucm567467.htm. Retrieved October 6, 2017.

"Highlights of Prescribing Information." Gilead.com. Gilead Sciences Inc., http://www.gilead.com/~/media/Files/pdfs/medicines/liver-disease/vosevi/vosevi_pi.pdf. Retrieved October 6, 2017.

"Vosevi is FDA approved." Vosevi.com. Gilead Sciences Inc., http://www.vosevi.com/. Retrieved October 6, 2017.