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Hep C Trial with Sovaprevir Has 85% Success Rate

August 20, 2012

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In a mid-stage trial, Achillion’s experimental drug, sovaprevir, demonstrated an excellent efficacy rate and safety profile.

Achillion hepatitis C drug shows promise in mid-stage study

Tue Aug 7, 2012 8:37pm EDT

(Reporting by Zeba Siddiqui in Bangalore; Editing by Anthony Kurian)

(Reuters) – Achillion Pharmaceuticals Inc said its experimental hepatitis C drug showed promising interim data in a mid-stage trial, sending its shares higher in extended trade.

The company said the drug sovaprevir, when given along with the standard therapy of pegylated interferon and ribavirin, showed no detectable virus level in a majority of patients four weeks after the end of the treatment period.

Of the 39 patients who received 12 weeks of additional standard therapy following 12 weeks of the combination therapy, a total of 33 patients in three different dosage arms showed sustained viral response a month later.

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  • stella

    85% and what are the long term side effects? Still not good enough.

  • Babybomer

    What are the short and long term side effects?

  • John Thompson

    when given along with the standard therapy of pegylated interferon and ribavirin. No Thanks !!

  • Waqas Saleem

    is genotype meter on this type of therapy?

  • Canio

    Niiice! I did 11 months interferon/ribavirin and had to add procrit due to anemia. It’s been 4 years now and undetectable. Sure it was the toughest thing ever, but my energy is great! I no longer have brain fog! I ski, play tennis, and scuba. This new therapy for 12 weeks?? If it was me, I would do it in a heartbeat. I have quality of life at age 58. 🙂

  • Ric

    I went through 24 weeks on and Abbott trial, with no interferon just ribavirin abt`450 abt`750 and Ritrovinal and have been virus free for almost 2 years. I never heard of any side effects and I felt great through the whole trial.
    Can’t imagen why this is not in the news.

    • Jane Plane

      What Genotype?

    • Can u elaborate more on exactly what this is?

    • PRP

      Ric, last month u stated it worked. Where did you go to get treated? sovaprevir not included? I guess the question is if we can get just the latter somewhere. Still winging it with brainfog and low energy.

  • Deb

    Having done two rounds of pegylated interferon & ribavarin I have been told new treatments involving interferon & ribavarin could cause my liver to crash. Enough already, it’s time for new treatments.

  • Dr.Ahmed Elshafei

    85% results !!!! with which genotype?????

  • pharmassest and bristol meyers has a combo therapy 1 drug made by each company and no peg 100% cure rate and then pharmassest pulled out they were well into stage 2 trials.There is a petition going start by margarert dulley trying to convince pharmessest to do the right thing and resume these trials.Encourage all to sign and to spread the word for anyone affected to also sign

  • clearwaterjim

    what genome?

  • Blueheron

    Testing negative 4 weeks post treatment means nothing – take it out a year. If negative then, that is a positive outcome.

  • Angelo

    I don’t think any of the new drugs that come out that must be taken with interferon and ribaviran will really make a killing. The 2 newest ones seem to have a SVR rate over 85% for genotype 1’s so I think most will be waiting (if they can) for drugs to come out without using interferon which seems to be in about 2014-2015 hopefully. Whatever comes out will surely be “fast tracked”.