Hepatitis C, table 1, Effects of Chronic Ethanol Administration on Rat Liver Proteasome Activities: Relationship With Oxidative Stress

Effects of Chronic Ethanol Administration on Rat Liver Proteasome Activities: Relationship With Oxidative Stress

table 1. Effects of Oral Ethanol Administration on Cellular Free Radical Targets and Peptidase Activities in Rat Liver

	Controls	Ethanol-rats

Lipid peroxidation (nmol MDA/g)	81.5 ± 6.7	93.67 ± 11.6^*
Cytosolic protein thiols (nmol/mg protein)	122.7 ± 1.0	123.0 ± 3.4^*
Protein carbonyls (nmol/mg protein)	2.35 ± 0.09	2.41 ± 0.18^*
Glutamine synthetase (nmol/min/mg protein)	156 ± 20	128 ± 29^*
ChT-L activity (nmol/30 min/mg protein)	11.52 ± 1.49	10.65 ± 1.6^*
PGPH activity (nmol/30 min/mg protein)	8.63 ± 0.84	7.96 ± 1.14^*
Protein (mg/g)	247.7 ± 10.4	273.0 ± 21.9^*

NOTE. Ethanol-treated rats were given 10% ethanol (vol/vol) as sole drinking fluid for 4 weeks. Values are means ± SEM for 6 rats per group. ^* Not significant.