Hepatitis C, table 1, High Prevalence of the His63AspHFE Mutation in Italian Patients With Porphyria Cutanea Tarda

High Prevalence of the His63Asp HFE Mutation in Italian Patients With Porphyria Cutanea Tarda

table 1. Allelic and Genotype Frequencies of Two Mutations of HFE in 68 Patients With PCT, in 128 Control Subjects From the General Population (Group A) and in 50 Patients With HCV Chronic Hepatitis and No Evidence of Porphyria (Group B)

	PCT (n = 68)	Controls		P
		Group A	Group B
		(n = 128)	(n = 50)

Alleles
Cys282Tyr	2/136 (1.5%)	2/256 (0.7%)	2/100 (2.0%)	NS
His63Asp	39/136 (28.7%)	33/256 (12.9%)	12/100 (12.0%)	<0.001^*
Genotypes
Cys282/Tyr282	2/68 (2.9%)	2/128 (1.5%)	2/50 (4.0%)	NS
Tyr282/Tyr282	0/68	0/128	0/50	NS
His63/Asp63	29/68 (42.6%)	29/128 (22.6%)	8/50 (16.0%)	0.005^*
Asp63/Asp63	5/68 (7.3%)	2/128 (1.5%)	2/50 (4.0%)	0.050^*

Abbreviation: NS, not significant. ^* PCT patients vs. Group A controls.