Hepatitis C, table 2, High Incidence of Allograft Cirrhosis in Hepatitis C

High Incidence of Allograft Cirrhosis in Hepatitis C Virus Genotype 1b Infection Following Transplantation: Relationship With Rejection Episodes

table 2. Evolution of Activity and Fibrosis in the First 5 Years After Liver Transplantation

Score	First Year	Second Year	Third Year	Fourth Year	Fifth Year

Grade (activity)^*	n = 78	n = 56	n = 35	n = 19	n = 13
No hepatitis, n (%)	5 (6.4)	1 (1.8)	3 (8.6)	1 (5.3)	0 (0)
Minimal, n (%)	20 (25.6)	9 (16.1)	5 (14.3)	2 (10.5)	2 (15.4)
Mild, n (%)	17 (21.8)	12 (21.4)	7 (20)	4 (21.1)	5 (53.8)
Moderate, n (%)	31 (39.7)	25 (44.6)	13 (37.1)	8 (42.1)	4 (30.8)
Severe, n (%)	5 (6.4)	9 (16.1)	7 (20)	4 (21.1)	2 (15.4)
Stage (fibrosis)	n = 78	n = 57	n = 35	n = 18	n = 13
None, n (%)	44 (56.4)	24 (42.1)	15 (42.9)	5 (27.8)	4 (30.8)
Fibrous portal expansion, n (%)	27 (34.6)	21 (36.8)	10 (28.6)	9 (50)	6 (46.2)
Bridging fibrosis, n (%)	4 (5.1)	9 (15.8)	7 (20)	1 (5.6)	3 (23.1)
Cirrhosis, n (%)	3 (3.8)	3 (5.3)	3 (8.6)	3 (16.7)	0 (0)

^* Activity was determined by combining the HAI (Knodell) scores for periportal necrosis (0-6), lobular degeneration and necrosis (0-4), and portal inflammation (0-4), and defined as follows: 1-2, minimal; 3-6, mild; 7-10, moderate; 11-14, severe.