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Molecular Basis for Persistent Hepatitis B Virus Infection In the Liver After Clearance of Serum Hepatitis B Surface Antigen

table  1.   Southern Blot Studies of Hepatic Nucleic Acids Amplified by Either RT-PCR Using Primers Complementary to the HBV Core and Surface Genes or Seminested PCR Using Primers Flanking the HBV DR Region

Patients Months After HBsAg Clearance RT-PCR for HBV RNA


Seminested PCR


HBV Core Gene Primers HBV Surface Gene Primers HBV DR Region Primers

Study group*
  1 3 + + +
  2 3 + +   -
  3 9  - + +
  4* 24   -  -  -
  5 46  -   - +
  6 47   -   -   -
  7dagger 67 + +   -
Controls
  HBsAg-positive 12/13 11/13 3/3
  HBsAg-negative 0/4 0/4 0/4

* All study group patients HBV-DNA-positive in the liver by PCR except for patient 4.8 Patients 1, 2, and 3 represent patients 1, 2, and 3 in Kuhns,8 whereas patients 4, 5, 6, and 7 in this table are patients 7, 4, 5, and 6, respectively, as tabulated in Kuhns.8
dagger HBV-DNA-positive in serum by PCR.8

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