When is Sovaldi™ contraindicated? | Hepatitis Central

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Sovaldi™ (sofosbuvir) and Hepatitis C

When is Sovaldi™ contraindicated?

The same contraindications that pertain to peginterferon and ribavirin also apply to the Sovaldi™ combination treatment. This combination treatment is contraindicated in pregnant women or those that may become pregnant as well as men whose female partner is pregnant, due to the risks for birth defects and fetal death associated with ribavirin.

The following chart provides information regarding potentially significant drug interactions with Sovaldi™ (the table is not all-inclusive). Alteration in dose or regimen may be recommended based on drug interaction studies or predicted interactions. (For more information regarding the effect of co-administration of these medications with Sovaldi™ combination therapy and recommendations for alterations in dose or regimen please visit www.Gilead.com.)

Drug Class Specific Drugs Within Class Contraindicated with Sovaldi™
Anticonvulsants Carbamazepine
Antimycobacterial Rifabutin
Herbal Supplements St. Johns’ wort (Hypericum perforatum)
HIV Protease Inhibitors Tipranavir/Ritonavir

While the following drugs were evaluated in clinical trials, it was determined that no dose adjustment was need when used in combination Sovaldi as they are without clinically significant interactions:

  • cyclosporine
  • darunavir/ritonavir
  • efavirenz
  • emtricitabine
  • methadone
  • raltegravir
  • rilpivirine
  • tacrolimus
  • tenofovir disoproxil fumarate

Last Updated: July 2014

"Full Prescribing Information." Gilead.com. Gilead Sciences, Inc., http://www.gilead.com/~/media/Files/pdfs/medicines/liver-disease/sovaldi/sovaldi_pi.pdf. Retrieved December 31, 2013.

"Patient Information: Sovaldi™." Gilead.com. Gilead Sciences, Inc., http://www.gilead.com/~/media/Files/pdfs/medicines/liver-disease/sovaldi/sovaldi_patient_pi.pdf. Retrieved December 31, 2013.

"Register for a SOVALDI Co-pay Coupon." Sovaldi.com. Gilead Sciences, Inc., https://www.sovaldi.com/copay-register.aspx. Retrieved December 31, 2013.

"Support Path." MySupportPath.com. Gilead Sciences, Inc., http://www.mysupportpath.com/. Retrieved December 31, 2013.

"U.S. Food and Drug Administration Approved Gilead's Sovaldi (Sofosbuvir) for the Treatment of Chronic Hepatitis C." Gilead.com. Gilead Sciences, Inc., http://investors.gilead.com/phoenix.zhtml?c=69964&p=irol-newsArticle&ID=1882800&highlight=. Retrieved December 31, 2013.